• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Down syndrome-related transient abnormal myelopoiesis is attributed to a specific erythro-megakaryocytic subpopulation with mutation.

作者信息

Nishinaka-Arai Yoko, Niwa Akira, Matsuo Shiori, Kazuki Yasuhiro, Yakura Yuwna, Hiroma Takehiko, Toki Tsutomu, Sakuma Tetsushi, Yamamoto Takashi, Ito Etsuro, Oshimura Mitsuo, Nakahata Tatsutoshi, Saito Megumu K

机构信息

Dept. of Clinical Application, Center for iPS cell Research and Application, Kyoto University, Kyoto.

Chromosome Engineering Research Center, Tottori University, Tottori, Japan.

出版信息

Haematologica. 2021 Feb 1;106(2):635-640. doi: 10.3324/haematol.2019.242693.

DOI:10.3324/haematol.2019.242693
PMID:32354872
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7849752/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddd0/7849752/2f8452ce89f8/106635.fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddd0/7849752/85329b505782/106635.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddd0/7849752/c1d0650bbe61/106635.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddd0/7849752/2f8452ce89f8/106635.fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddd0/7849752/85329b505782/106635.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddd0/7849752/c1d0650bbe61/106635.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddd0/7849752/2f8452ce89f8/106635.fig3.jpg

相似文献

1
Down syndrome-related transient abnormal myelopoiesis is attributed to a specific erythro-megakaryocytic subpopulation with mutation.唐氏综合征相关的短暂性异常髓细胞生成归因于具有突变的特定红系-巨核细胞亚群。
Haematologica. 2021 Feb 1;106(2):635-640. doi: 10.3324/haematol.2019.242693.
2
Transient abnormal myelopoiesis of a newborn not associated with chromosome 21 abnormalities or GATA1 mutations.新生儿短暂性异常髓系造血，与21号染色体异常或GATA1突变无关。
Pediatr Blood Cancer. 2015 Feb;62(2):353-355. doi: 10.1002/pbc.25226. Epub 2014 Aug 30.
3
Placental Pathology in Down Syndrome-Associated Transient Abnormal Myelopoiesis.唐氏综合征相关短暂性髓系造血异常的胎盘病理学。
Arch Pathol Lab Med. 2020 Mar;144(3):388-393. doi: 10.5858/arpa.2018-0248-RS. Epub 2019 Apr 10.
4
Liver fibrosis with hypereosinophilia causing transient abnormal myelopoiesis.伴有嗜酸性粒细胞增多的肝纤维化导致短暂异常髓系造血。
Pediatr Int. 2016 Nov;58(11):1222-1225. doi: 10.1111/ped.13093. Epub 2016 Oct 6.
5
Transient abnormal myelopoiesis in a phenotypically normal newborn with polyclonal trisomy 21.一名表型正常的新生儿，伴有多克隆性21三体综合征，出现短暂异常髓系造血。
Int J Hematol. 2014 Jun;99(6):794-7. doi: 10.1007/s12185-014-1584-0. Epub 2014 Apr 26.
6
Transient abnormal myelopoiesis in non-Down syndrome neonate.非唐氏综合征新生儿的短暂性异常骨髓造血
Pediatr Int. 2015;57(1):e14-7. doi: 10.1111/ped.12500.
7
Naturally occurring oncogenic GATA1 mutants with internal deletions in transient abnormal myelopoiesis in Down syndrome.在唐氏综合征的暂时性血细胞质异常中，天然存在的致癌 GATA1 突变体具有内部缺失。
Blood. 2013 Apr 18;121(16):3181-4. doi: 10.1182/blood-2012-01-405746. Epub 2013 Feb 25.
8
Sensitive detection of GATA1 mutations using complementary DNA-based analysis for transient abnormal myelopoiesis associated with the Down syndrome.应用基于互补 DNA 的分析技术对唐氏综合征相关暂时性血细胞质异常进行 GATA1 突变的敏感检测。
Int J Lab Hematol. 2022 Apr;44(2):349-355. doi: 10.1111/ijlh.13756. Epub 2021 Nov 10.
9
[Abnormal hematopoiesis in Down syndrome].[唐氏综合征中的异常造血]
Rinsho Ketsueki. 2014 Oct;55(10):1738-47.
10
Prominent megakaryocytic dysplasia after regression of transient abnormal myelopoiesis associated with GATA-1 mutation.与GATA-1突变相关的短暂异常髓系造血消退后显著的巨核细胞发育异常。
J Pediatr Hematol Oncol. 2012 Nov;34(8):640. doi: 10.1097/MPH.0b013e31826e7dba.

引用本文的文献

1
Advances in molecular characterization of myeloid proliferations associated with Down syndrome.与唐氏综合征相关的髓系增殖性疾病分子特征研究进展
Front Genet. 2022 Aug 10;13:891214. doi: 10.3389/fgene.2022.891214. eCollection 2022.
2
NUDT15 variants confer high incidence of second malignancies in children with acute lymphoblastic leukemia.NUDT15 变异导致急性淋巴细胞白血病患儿发生二次恶性肿瘤的几率较高。
Blood Adv. 2021 Dec 14;5(23):5420-5428. doi: 10.1182/bloodadvances.2021005507.
3
N-Acetylcysteine prevents amyloid-β secretion in neurons derived from human pluripotent stem cells with trisomy 21.

本文引用的文献

1
Transient Abnormal Myelopoiesis and AML in Down Syndrome: an Update.唐氏综合征中的短暂异常骨髓造血和急性髓系白血病：最新进展
Curr Hematol Malig Rep. 2016 Oct;11(5):333-41. doi: 10.1007/s11899-016-0338-x.
2
Single-cell profiling of human megakaryocyte-erythroid progenitors identifies distinct megakaryocyte and erythroid differentiation pathways.人类巨核细胞-红系祖细胞的单细胞分析确定了不同的巨核细胞和红系分化途径。
Genome Biol. 2016 May 3;17:83. doi: 10.1186/s13059-016-0939-7.
3
Systematic Cellular Disease Models Reveal Synergistic Interaction of Trisomy 21 and GATA1 Mutations in Hematopoietic Abnormalities.
N-乙酰半胱氨酸可防止 21 三体人多能干细胞来源的神经元中淀粉样β分泌。
Sci Rep. 2021 Aug 30;11(1):17377. doi: 10.1038/s41598-021-96697-7.
4
Pluripotent stem cell model of early hematopoiesis in Down syndrome reveals quantitative effects of short-form GATA1 protein on lineage specification.唐氏综合征早期造血多能干细胞模型揭示短型 GATA1 蛋白对谱系特化的定量影响。
PLoS One. 2021 Mar 29;16(3):e0247595. doi: 10.1371/journal.pone.0247595. eCollection 2021.
5
Molecular Mechanisms of the Genetic Predisposition to Acute Megakaryoblastic Leukemia in Infants With Down Syndrome.唐氏综合征婴儿急性巨核细胞白血病遗传易感性的分子机制
Front Oncol. 2021 Mar 11;11:636633. doi: 10.3389/fonc.2021.636633. eCollection 2021.
6
Elucidation of the Pathogenesis of Autoinflammatory Diseases Using iPS Cells.利用诱导多能干细胞阐明自身炎症性疾病的发病机制
Children (Basel). 2021 Feb 1;8(2):94. doi: 10.3390/children8020094.
系统性细胞疾病模型揭示了21三体与GATA1突变在造血异常中的协同相互作用。
Cell Rep. 2016 May 10;15(6):1228-41. doi: 10.1016/j.celrep.2016.04.031. Epub 2016 Apr 28.
4
Pluripotent stem cells reveal erythroid-specific activities of the GATA1 N-terminus.多能干细胞揭示了GATA1 N端的红系特异性活性。
J Clin Invest. 2015 Mar 2;125(3):993-1005. doi: 10.1172/JCI75714. Epub 2015 Jan 26.
5
ReactomeFIViz: a Cytoscape app for pathway and network-based data analysis.ReactomeFIViz：一款用于基于通路和网络的数据分析的Cytoscape应用程序。
F1000Res. 2014 Jul 1;3:146. doi: 10.12688/f1000research.4431.2. eCollection 2014.
6
Wnt signaling controls the specification of definitive and primitive hematopoiesis from human pluripotent stem cells.Wnt 信号通路控制着人类多能干细胞向定型和原始造血的分化。
Nat Biotechnol. 2014 Jun;32(6):554-61. doi: 10.1038/nbt.2915. Epub 2014 May 18.
7
Repeating pattern of non-RVD variations in DNA-binding modules enhances TALEN activity.DNA结合模块中非RVD变异的重复模式增强了TALEN活性。
Sci Rep. 2013 Nov 29;3:3379. doi: 10.1038/srep03379.
8
The landscape of somatic mutations in Down syndrome-related myeloid disorders.唐氏综合征相关髓系疾病中体细胞突变的全景。
Nat Genet. 2013 Nov;45(11):1293-9. doi: 10.1038/ng.2759. Epub 2013 Sep 22.
9
Robust and highly-efficient differentiation of functional monocytic cells from human pluripotent stem cells under serum- and feeder cell-free conditions.在无血清和无饲养细胞条件下，从人多能干细胞中高效且稳定地分化出功能性单核细胞。
PLoS One. 2013;8(4):e59243. doi: 10.1371/journal.pone.0059243. Epub 2013 Apr 3.
10
Trisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cells.通过诱导多能干细胞揭示与 21 三体相关的人类原始造血缺陷。
Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17573-8. doi: 10.1073/pnas.1211175109. Epub 2012 Oct 8.