Department of Obstetrics and Gynaecology, University Hospital of Ioannina, Ioannina, Greece
Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, U.K.
In Vivo. 2020 May-Jun;34(3):1445-1449. doi: 10.21873/invivo.11927.
In Greece the population-level impact of HPV vaccination is unknown due to lack of official registries. This study presents in a pragmatic frame the comparison of cervical pathology data between HPV-vaccinated and unvaccinated women referred for colposcopy.
This is an observational prospective cohort study performed in 7 academic Obstetrics and Gynaecology Departments across Greece between 2009-2019. Cases were women that had completed HPV vaccination before coitarche and were referred for colposcopy due to abnormal cytology. For each vaccinated woman an unvaccinated matched control was selected.
A total of 849 women who had been vaccinated before coitarche and 849 unvaccinated controls were recruited. The combination of cytological, colposcopic and molecular findings necessitated treatment in only a single case among vaccinated (0.1%) and in 8.4% among unvaccinated.
HPV vaccination at a proper age can markedly reduce development of severe cervical precancers and consequently the need for treatment, as well as their long-term related obstetrical morbidity.
由于缺乏官方登记，希腊尚不清楚 HPV 疫苗接种对人群的影响。本研究以实用框架的形式呈现了 HPV 疫苗接种和未接种女性转诊行阴道镜检查的宫颈病理数据比较。
这是一项在希腊 7 个学术妇产科部门于 2009-2019 年进行的观察性前瞻性队列研究。病例是在初潮前完成 HPV 疫苗接种且因细胞学异常而转诊行阴道镜检查的女性。对于每一位接种疫苗的女性，均选择了一名未接种疫苗的匹配对照。
共招募了 849 名初潮前接种 HPV 疫苗的女性和 849 名未接种疫苗的对照组。仅在接种组的 1 例（0.1%）和未接种组的 8.4%中需要治疗，需要综合细胞学、阴道镜和分子检查结果。
在适当的年龄接种 HPV 疫苗可显著减少严重宫颈前病变的发生，并因此减少治疗需求及其相关的长期产科发病率。
