Keleş Ali, Doğuizi Sibel, Şahin Nursel Muratoğlu, Koç Mustafa, Aycan Zehra
Department of Ophthalmology, Cizre State Hospital, Şırnak, Turkey.
Ulucanlar Eye Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
Cornea. 2020 Aug;39(8):935-939. doi: 10.1097/ICO.0000000000002345.
To evaluate the anterior segment parameters in patients with osteogenesis imperfecta (OI) compared with healthy control subjects.
Seventeen patients with OI and 19 age-matched healthy controls were included into this cross-sectional case-control study. Corneal topographic, topometric and Belin-Ambrósio Enhanced Ectasia Display III analysis, corneal densitometry (12-mm corneal diameter), and lens densitometry measurements were obtained by using the Pentacam HR-Scheimpflug imaging system (Oculus, Wetzlar, Germany). The corneal endothelial cell properties were determined by specular microscopy.
In comparison to the control group, patients with OI had significantly higher front astigmatism (0.8 ± 0.4 vs. 1.4 ± 1.1 mm, P = 0.026), thinner thinnest corneal thickness (556.4 ± 32.7 μm vs. 482.5 ± 66.9 μm, P = 0.002), smaller corneal volume (62.4 ± 3.5 mm vs. 53.7 ± 6.4 mm, P < 0.001), lower anterior chamber depth (3.2 ± 0.3 mm vs. 3.0 ± 0.2 mm, P = 0.009), higher index of vertical asymmetry (0.1 ± 0.04 vs. 0.2 ± 0.11, P < 0.001), higher posterior elevation (6.0 ± 2.7 μm vs. 11.9 ± 7.8 μm, P = 0.002), lower maximum Ambrósio relational thickness indice (456.6 ± 67.5 vs. 365.6 ± 115.7, P = 0.009), and higher final "D" value (0.7 ± 0.4 vs. 2.0 ± 1.6, P = 0.002). The corneal and lens densitometry values were similar in all concentric zones and layers in both groups except that 6 to 10 mm in the center. Corneal densitometry was higher in eyes with OI than that in the control group (9.8 ± 1.7 and 8.8 ± 1.0, P = 0.010). There was no difference in endothelial cell morphology between the groups (P > 0.05).
The morphologic parameters determined on the corneal analysis are in general agreement with the known pathophysiology of OI. Corneal analysis may prove useful in monitoring patients with OI in clinical practice.
评估成骨不全症（OI）患者与健康对照者的眼前节参数。
本横断面病例对照研究纳入了17例OI患者和19例年龄匹配的健康对照者。使用Pentacam HR-Scheimpflug成像系统（德国韦茨拉尔奥culus公司）进行角膜地形图、角膜测厚及Belin-Ambrósio增强型扩张显示III分析、角膜密度测量（角膜直径12mm）和晶状体密度测量。通过镜面显微镜检查确定角膜内皮细胞特性。
与对照组相比，OI患者的前散光显著更高（0.8±0.4对1.4±1.1mm，P = 0.026），最薄角膜厚度更薄（556.4±32.7μm对482.5±66.9μm，P = 0.002），角膜体积更小（62.4±3.5mm对53.7±6.4mm，P < 0.001），前房深度更低（3.2±0.3mm对3.0±0.2mm，P = 0.009），垂直不对称指数更高（0.1±0.04对0.2±0.11，P < 0.001），后表面隆起更高（6.0±2.7μm对11.9±7.8μm，P = 0.002），最大Ambrósio相关厚度指数更低（456.6±67.5对365.6±115.7，P = 0.009），最终“D”值更高（0.7±0.4对2.0±1.6，P = 0.002）。除中央6至10mm外，两组所有同心区和层的角膜和晶状体密度测量值相似。OI患者眼睛的角膜密度高于对照组（9.8±1.7和8.8±1.0，P = 0.010）。两组间内皮细胞形态无差异（P > 0.05）。
角膜分析确定的形态学参数总体上与OI已知的病理生理学一致。角膜分析在临床实践中监测OI患者可能有用。
