原发性先天性青光眼患者的角膜密度测量与地形图分析

Corneal densitometry and topography in patients with primary congenital glaucoma.

作者信息

Morales-Fernández L, Perucho-González L, Martinez-de-la-Casa J M, Perez-Garcia P, Sáenz-Francés F, Benito-Pascual B, Nieves-Moreno M, García-Bella J, Arriola-Villalobos P, García-Feijoo J

机构信息

Ophthalmology Unit, Hospital Clinico San-Carlos, Instituto de Investigacion Sanitaria del Hospital Clinico San-Carlos (IdISSC), Madrid, Spain.

出版信息

J Fr Ophtalmol. 2020 Oct;43(8):697-703. doi: 10.1016/j.jfo.2019.11.035. Epub 2020 Aug 10.

DOI:10.1016/j.jfo.2019.11.035

PMID:32792292

Abstract

OBJECTIVE

To compare corneal densitometry and topography variables in patients with primary congenital glaucoma (PCG) and healthy subjects.

MATERIAL AND METHODS

Cross sectional study, consecutive recruitment with gender- and age-matched control group. Forty eyes of 40 patients in each group were studied with Pentacam corneal topography. The variables compared between the two groups were: intraocular pressure (IOP), visual acuity (VA) and Pentacam (Oculus, Wetzlar, Germany) corneal topography measurements: mean and maximum keratometry (Km, Kmax), cylinder (Cyl), anterior elevation apex (AEA), central anterior elevation (CAE), maximum anterior elevation (MAE), posterior elevation apex (PEA), central posterior elevation (CPE), maximum posterior elevation (MPE), pachymetry and anterior, mid-stromal and posterior corneal densitometry in the 0-2mm, 2-6mm, 6-10mm zones.

RESULTS

Significant differences between patients and healthy controls were detected in the topographic variables MAE (P=0.002) and MPE (P<0.001), and in all the densitometry variables (anterior, mid-stromal, posterior for the 0-2mm, 2-6mm and 6-10mm zones) (P<0.001 each). In the PCG group, negative correlation was observed between VA and total densitometry (r=-0.49; P=0.004).

CONCLUSION

Patients with PCG and healthy subjects display differences in corneal densitometry and topographic measurements. PCG patients show greater corneal density with an inverse relationship between visual acuity and higher elevation (anterior and posterior values).

摘要

目的

比较原发性先天性青光眼（PCG）患者与健康受试者的角膜密度测量和地形图变量。

材料与方法

横断面研究，连续招募性别和年龄匹配的对照组。每组40例患者的40只眼采用Pentacam角膜地形图仪进行研究。两组之间比较的变量包括：眼压（IOP）、视力（VA）以及Pentacam（德国韦茨拉尔奥culus公司）角膜地形图测量值：平均和最大角膜曲率（Km、Kmax）、柱镜（Cyl）、前表面高度顶点（AEA）、中央前表面高度（CAE）、最大前表面高度（MAE）、后表面高度顶点（PEA）、中央后表面高度（CPE）、最大后表面高度（MPE）、角膜厚度测量以及0 - 2mm、2 - 6mm、6 - 10mm区域的前、基质中部和后角膜密度测量。

结果

在地形图变量MAE（P = 0.002）和MPE（P < 0.001）以及所有密度测量变量（0 - 2mm、2 - 6mm和6 - 10mm区域的前、基质中部、后）（各P < 0.001）方面，患者与健康对照组之间存在显著差异。在PCG组中，观察到VA与总密度测量值之间呈负相关（r = -0.49；P = 0.004）。