School of Medicine, Zhejiang University, Hangzhou, 310058, China.
Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, 310000, China.
Sci Rep. 2020 Apr 30;10(1):7356. doi: 10.1038/s41598-020-63909-5.
To determine the causality of micro-nutrients concentrations and risk of ovarian cancer using the Mendelian randomization approach. Analyses were conducted using summary statistics data for SNPs robustly associated with concentrations of thirteen micro-nutrients (iron, copper, zinc, calcium, magnesium, phosphorus, selenium, vitamin A, β-carotene, vitamin B6, vitamin B12, vitamin E, folate). The corresponding data for ovarian cancer were obtained from the Ovarian Cancer Association Consortium (25,509 cases and 40,941 controls). In standard Mendelian randomization analysis, the odds ratios (OR) of invasive epithelial ovarian cancer were 0.14 (95% CI, 0.03-0.70; P = 0.02) per 0.1 mmol/L (about one standard deviation, SD) increase in genetically predicted magnesium concentration, 1.04 (95% CI, 1.00-1.09; P = 0.03) per 0.3 μmol/liter (about one SD) increase in genetically predicted β-carotene concentration. The OR of low malignant potential tumours were 0.82 (95% CI, 0.76-0.90; P = 1.01 × 10) per 0.3 μmol/liter (about one SD) increase in β-carotene concentration, 1.42 (95% CI, 1.21-1.68; P = 3 × 10) per 153 pmol/L (about one SD) increase in vitamin B12 concentration, 0.21 (95% CI, 0.06-0.76; P = 0.02) per 6 mg/L (about one SD) increase in vitamin E concentration. No significant associations of other micro-nutrients and ovarian cancer were observed. This study found that an increased risk of invasive epithelial ovarian cancer was observed with a genetically higher concentration of β-carotene, whereas a decreased risk of invasive epithelial ovarian cancer was found with a higher concentration of magnesium. As for low malignant potential tumours, increased concentration of vitamin B12 could increase the risk of low malignant potential tumours, while increased concentrations of β-carotene and vitamin E could lower the risk of low malignant potential tumours.
使用孟德尔随机化方法来确定微量营养素浓度与卵巢癌风险的因果关系。分析使用与 13 种微量营养素（铁、铜、锌、钙、镁、磷、硒、维生素 A、β-胡萝卜素、维生素 B6、维生素 B12、维生素 E、叶酸）浓度密切相关的 SNP 的汇总统计数据进行。卵巢癌的数据来自卵巢癌协会联盟（25509 例病例和 40941 例对照）。在标准的孟德尔随机化分析中，镁浓度每增加 0.1 毫摩尔/升（约一个标准差，SD），侵袭性上皮性卵巢癌的比值比（OR）为 0.14（95%CI，0.03-0.70；P=0.02），β-胡萝卜素浓度每增加 0.3 微摩尔/升（约一个 SD），OR 为 1.04（95%CI，1.00-1.09；P=0.03）。低恶性潜能肿瘤的 OR 为β-胡萝卜素浓度每增加 0.3 微摩尔/升（约一个 SD），为 0.82（95%CI，0.76-0.90；P=1.01×10），维生素 B12 浓度每增加 153 皮摩尔/升（约一个 SD），为 1.42（95%CI，1.21-1.68；P=3×10），维生素 E 浓度每增加 6 毫克/升（约一个 SD），为 0.21（95%CI，0.06-0.76；P=0.02）。未观察到其他微量营养素与卵巢癌的显著关联。本研究发现，β-胡萝卜素浓度升高与侵袭性上皮性卵巢癌风险增加有关，而镁浓度升高则与侵袭性上皮性卵巢癌风险降低有关。对于低恶性潜能肿瘤，维生素 B12 浓度升高可能会增加低恶性潜能肿瘤的风险，而β-胡萝卜素和维生素 E 浓度升高则可能降低低恶性潜能肿瘤的风险。
