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基于1H-NMR的妊娠期甲状腺功能减退症脐带血代谢组学分析

1H-NMR based metabolomic profiling of cord blood in gestational hypothyroidism.

作者信息

Zhao Chunchao, Ge Jun, Jiao Ruifen, Li Xia, Li Yuan, Quan Huili, Yu Tianxiao, Xu Hong, Li Jianguo, Guo Qing, Wang Wenju

机构信息

Clinical Research Center for Obstetrics and Gynecology, Shijiazhuang Obstetrics and Gynecology Hospital, Shijiazhuang 050000, China.

Department of Systems Biology, Institute of Biomedical Sciences, Shanxi University, Taiyuan 030006, China.

出版信息

Ann Transl Med. 2020 Mar;8(6):296. doi: 10.21037/atm.2020.03.91.

DOI:10.21037/atm.2020.03.91
PMID:32355740
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7186693/
Abstract

BACKGROUND

Gestational hypothyroidism (GHT) is a common pregnancy-related thyroid disfunction. The adverse outcomes by GHT has been increasingly recognized, leading to more public awareness of the disease. However, comprehensive understanding of the prognosis of GHT has not yet achieved. Metabolomics is a powerful tool in evaluation of disease outcomes, and cord blood represents an excellent candidate for the investigation of gestational outcomes.

METHODS

In the present study, we performed 1H-NMR based metabolomics on cord blood of 18 pregnant women with GHT and 18 non hypothyroidism (NHT) control.

RESULTS

The metabolomic profile of GHT was separated with the NHT control. A total of 8 metabolites with altered abundances were observed, among which Creatinine and O-Phosphocholine were elevated and the others were downregulated in GHT. Spearman rank correlation suggested that the eight differential metabolites were correlated with the GHT related thyroid hormones. Pathway analysis of the differential metabolites indicated that two metabolic pathways were significantly altered in GHT (adjusted P<0.05), including tyrosine metabolism, phenylalanine, tyrosine and tryptophan biosynthesis. Enrichment analysis of the differential metabolites against disease-associated metabolite sets suggested that GHT was associated with disease risks of non-insulin dependent diabetes mellitus, isovaleric acidemia, and methylmalonic aciduria.

CONCLUSIONS

The results of this study revealed GHT associated metabolic changes in cord blood, providing insights into the metabolic intermediates between GHT and its related disease risks.

摘要

背景

妊娠期甲状腺功能减退（GHT）是一种常见的妊娠相关甲状腺功能障碍。GHT的不良后果已得到越来越多的认识，这使得公众对该疾病的认识有所提高。然而，尚未全面了解GHT的预后情况。代谢组学是评估疾病结局的有力工具，而脐血是研究妊娠结局的理想样本。

方法

在本研究中，我们对18例患有GHT的孕妇和18例非甲状腺功能减退（NHT）对照孕妇的脐血进行了基于1H-NMR的代谢组学分析。

结果

GHT的代谢组学图谱与NHT对照有所区分。共观察到8种丰度改变的代谢物，其中肌酐和O-磷酸胆碱在GHT中升高，其他代谢物下调。Spearman等级相关性分析表明，这8种差异代谢物与GHT相关的甲状腺激素有关。差异代谢物的通路分析表明，GHT中有两条代谢通路发生了显著改变（校正P<0.05），包括酪氨酸代谢、苯丙氨酸、酪氨酸和色氨酸生物合成。针对疾病相关代谢物集对差异代谢物进行的富集分析表明，GHT与非胰岛素依赖型糖尿病、异戊酸血症和甲基丙二酸尿症的疾病风险相关。

结论

本研究结果揭示了GHT在脐血中相关的代谢变化，为了解GHT与其相关疾病风险之间的代谢中间体提供了线索。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c3/7186693/146d4395cf1f/atm-08-06-296-fS.4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c3/7186693/52e4946f05b5/atm-08-06-296-f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c3/7186693/146d4395cf1f/atm-08-06-296-fS.4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c3/7186693/52e4946f05b5/atm-08-06-296-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c3/7186693/6955d57ef06c/atm-08-06-296-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c3/7186693/7d236772135f/atm-08-06-296-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c3/7186693/f21bdcd01592/atm-08-06-296-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c3/7186693/a0b7f9ac259b/atm-08-06-296-fS.1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c3/7186693/6bee3331d86c/atm-08-06-296-fS.2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c3/7186693/60c446a4f767/atm-08-06-296-fS.3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c3/7186693/146d4395cf1f/atm-08-06-296-fS.4.jpg

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