Mandia Luca, Cavoretto Paolo, Duca Piergiorgio, Candiani Massimo, Cetin Irene, Savasi Valeria
Unit of Obstetrics and Gynecology, Department of Biomedical and Clinical Sciences, ASST Fatebenefratelli Sacco, University of Milan, Via G. B. Grassi, 74, 20157 Milan, Italy.
Centre for Fetal Research Giorgio Pardi, University of Milan, 20100 Milan, Italy.
Diagnostics (Basel). 2020 Apr 26;10(5):254. doi: 10.3390/diagnostics10050254.
Oocyte donations (OD) represent 4.5% of all in vitro fertilization (IVF) cycles. While OD pregnancies face increased risks of obstetrical complications, especially pregnancy-induced hypertension and pre-eclampsia (PE), little is known about the physiology and the physiopathology of placentation. We performed a prospective case-control study to analyze uterine artery Doppler pulsatility index (UtA-PI) and serum maternal 17β-estradiol (17β-E) at 11 + 0 to 13 + 6 weeks' gestation in singleton pregnancies with different modes of conception. Study groups were: 55 OD, 48 IVF with autologous oocytes from fresh cycles (Autologous-Fresh IVF), 10 IVF with autologous oocytes from frozen cycles (Autologous-Frozen IVF) and 122 spontaneously conceived pregnancies (SC). The mean UtA-PI and serum maternal 17β-E at 11 to 13 + 6 weeks were significantly lower in OD as compared to SC and autologous IVF, either from fresh or frozen cycles. Oocyte donation presents lower UtA-PI and lower serum 17β-E in the first trimester of pregnancy. The etiology of these particularr differences is likely multifactorial and deserves further investigation.
卵母细胞捐赠（OD）占所有体外受精（IVF）周期的4.5%。虽然OD妊娠面临产科并发症风险增加，尤其是妊娠高血压和先兆子痫（PE），但关于胎盘形成的生理学和病理生理学知之甚少。我们进行了一项前瞻性病例对照研究，以分析单胎妊娠在妊娠11 + 0至13 + 6周时不同受孕方式下的子宫动脉多普勒搏动指数（UtA-PI）和母体血清17β-雌二醇（17β-E）。研究组包括：55例OD、48例新鲜周期自体卵母细胞IVF（自体新鲜IVF）、10例冷冻周期自体卵母细胞IVF（自体冷冻IVF）和122例自然受孕妊娠（SC）。与SC以及新鲜或冷冻周期的自体IVF相比，OD在妊娠11至13 + 6周时的平均UtA-PI和母体血清17β-E显著降低。卵母细胞捐赠在妊娠早期呈现较低的UtA-PI和较低的血清17β-E。这些特殊差异的病因可能是多因素的，值得进一步研究。
