Department of Biological Sciences, University of Alabama, Tuscaloosa, AL 35487, USA.
Genetics Graduate Training Program, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.
Int J Mol Sci. 2020 Apr 26;21(9):3055. doi: 10.3390/ijms21093055.
provides a powerful genetic model system in which to investigate the molecular mechanisms underlying neurodegenerative diseases. In this review, we discuss recent progress in modeling Alzheimer's Disease, Parkinson's Disease, Amyotrophic Lateral Sclerosis (ALS), Huntington's Disease, Ataxia Telangiectasia, and neurodegeneration related to mitochondrial dysfunction or traumatic brain injury. We close by discussing recent progress using models of neural regeneration and how these are likely to provide critical insights into future treatments for neurodegenerative disorders.
提供了一个强大的遗传模型系统，可用于研究神经退行性疾病的分子机制。在这篇综述中，我们讨论了近年来在建模阿尔茨海默病、帕金森病、肌萎缩侧索硬化症（ALS）、亨廷顿病、共济失调毛细血管扩张症以及与线粒体功能障碍或创伤性脑损伤相关的神经退行性变方面的最新进展。最后，我们讨论了使用神经再生模型的最新进展，以及这些模型如何为神经退行性疾病的未来治疗提供重要见解。
