Obafemi Olabisi Tajudeen, Ayeleso Ademola Olabode, Adewale Olusola Bolaji, Unuofin Jeremiah, Ekundayo Bidemi Emmanuel, Ntwasa Monde, Lebelo Sogolo Lucky
Department of Life and Consumer Sciences, School of Agriculture and Life Sciences, University of South Africa, 1710, Johannesburg, South Africa.
Biochemistry Programme, College of Agriculture, Engineering and Science, Bowen University, PMB 284, Iwo, Osun State, Nigeria.
Heliyon. 2024 Dec 31;11(1):e41605. doi: 10.1016/j.heliyon.2024.e41605. eCollection 2025 Jan 15.
Animal models have become veritable tools in gaining insight into the pathogenesis and progression of several human diseases. These models could range in complexity from to non-human primates. With the aid of these animal models, a lot of new knowledge has been gained about several diseases which otherwise would not have been possible. Most times, the utilization of these animal models is predicated on the level of homology they share with humans, which suggests that outcomes of studies using them could be extrapolated to humans. However, this has not always been the case. is becoming increasingly relevant as preferred model for understanding the biochemical basis of several human diseases. Apart from its relatively short lifespan, high fecundity and ease of rearing, the simplicity of its genome and lower redundancy of its genes when compared with vertebrate models, as well as availability of genetic tool kit for easy manipulation of its genome, have all contributed to its emergence as a valid animal model of human diseases. This review aimed at highlighting the contributions of selected animal models in biomedical research with a focus on the relevance of in understanding the biochemical basis of some diseases that have continued to plague mankind.
动物模型已成为深入了解多种人类疾病发病机制和进展的名副其实的工具。这些模型的复杂程度从[此处原文缺失相关内容]到非人类灵长类动物不等。借助这些动物模型，人们已经获得了许多关于多种疾病的新知识，否则这些知识是不可能获得的。大多数情况下，这些动物模型的使用是基于它们与人类的同源程度，这表明使用它们进行研究的结果可以外推到人类。然而，情况并非总是如此。[此处原文缺失相关内容]作为理解多种人类疾病生化基础的首选模型正变得越来越重要。除了其相对较短的寿命、高繁殖力和易于饲养外，与脊椎动物模型相比，其基因组的简单性和基因冗余度较低，以及有用于轻松操纵其基因组的基因工具包，所有这些都促使它成为人类疾病的有效动物模型。这篇综述旨在突出选定动物模型在生物医学研究中的贡献，重点是[此处原文缺失相关内容]在理解一些持续困扰人类的疾病生化基础方面的相关性。
