Liu Ruijia, Yu Xudong, Zhang Liping, Zhang Hong, Gong Yuanyuan, Wu Kang, Yan Shuting, Song Lianying
Graduate School of Beijing University of Chinese Medicine.
The First Department of Neurology.
Medicine (Baltimore). 2020 May;99(18):e19998. doi: 10.1097/MD.0000000000019998.
Acute cerebral infarction is a clinically common cerebrovascular disease. Acute cerebral infarction is characterized by sudden onset, dangerous illness, high risk of death, and disability. Computed tomography perfusion imaging can detect abnormal brain tissue perfusion 30 minutes after the onset of cerebral ischemia, providing the earliest and most valuable information for clinical diagnosis and treatment. In recent years, the effect of traditional Chinese medicine on acute cerebral infarction has been remarkable.
METHODS/DESIGN: This study plan randomly divided eligible acute cerebral infarction patients into two groups. Patients in the control group will be treated with conventional Western medicine; patients in the intervention group will be treated with traditional Chinese medicine cooperative therapy on the basis of conventional Western medicine. The curative effects will be selected before treatment, 2 weeks after treatment, and 3 months follow-up. The changes in CT imaging evaluation, NIHSS score, and BI index of the two groups of patients will be observed.
We aim to provide higher evidence-based medical evidence for traditional Chinese medicine treatment of acute cerebral infarction. And clarify the application value of computed tomography perfusion imaging in the diagnosis and efficacy evaluation of acute cerebral infarction.
ClinicalTrials.gov, ChiCTR2000030230, Registered on 03 March 2020.
急性脑梗死是临床上常见的脑血管疾病。急性脑梗死具有起病急、病情凶险、死亡和致残风险高的特点。计算机断层扫描灌注成像能够在脑缺血发作30分钟后检测到脑组织灌注异常，为临床诊断和治疗提供最早且最有价值的信息。近年来，中医药对急性脑梗死的治疗效果显著。
方法/设计：本研究计划将符合条件的急性脑梗死患者随机分为两组。对照组患者采用传统西医治疗；干预组患者在传统西医治疗的基础上采用中医药协同治疗。疗效观察选取治疗前、治疗2周后及3个月随访时。观察两组患者CT影像评估、美国国立卫生院卒中量表（NIHSS）评分及巴氏指数（BI）的变化。
我们旨在为中医药治疗急性脑梗死提供更高质量的循证医学证据。并阐明计算机断层扫描灌注成像在急性脑梗死诊断及疗效评估中的应用价值。
ClinicalTrials.gov，ChiCTR2000030230，于2020年3月3日注册。
