Mitchell J C
Mayo Clin Proc. 1977 May;52(5):281-8.
A group of 43 juvenile diabetic patients accepted for renal transplantation and followed up for as long as 5 years was studied. The cumulative survivial of the group was 66% at 1 year and 58% at 5 years. The 1-year survival of those receiving cadaveric renal allografts (65%) or of those on dialysis alone (55%) was less than the survival of those after living related donor transplantation (88%). The major morbid sequelae included retinopathy, neuropathy, and peripheral vascular disease. While patients were on dialysis, blindness increased, with 44% of the bilateral blindness and 27% of the unilateral blindness representing new cases. After transplantation, permanent unilateral or bilateral blindness developed in an additional 12% of the patients. Severe neuropathy progressed rapidly in patients on dialysis and improved after transplantation in all. Fifty percent of the patients who survived transplantation 1 year or more required amputation of one or more extremities. Only 25% of the patients who survived 1 year after transplantation were without blindness, severe peripheral vascular problems, or both.
对一组43名接受肾移植并随访长达5年的青少年糖尿病患者进行了研究。该组患者1年时的累积生存率为66%，5年时为58%。接受尸体肾移植者（65%）或单纯接受透析者（55%）的1年生存率低于亲属活体供肾移植者（88%）。主要的并发症包括视网膜病变、神经病变和周围血管疾病。患者在透析期间失明情况增加，44%的双侧失明和27%的单侧失明为新发病例。移植后，另有12%的患者出现永久性单侧或双侧失明。严重神经病变在透析患者中进展迅速，移植后全部有所改善。移植后存活1年或更长时间的患者中有50%需要截肢一个或多个肢体。移植后存活1年的患者中只有25%没有失明、严重周围血管问题或两者皆无。
