El-Eshmawy Mervat M, Gad Doaa F, El-Baiomy Azza A
Internal Medicine Department, Mansoura Specialized Medical Hospital, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Endocr Metab Immune Disord Drug Targets. 2020;20(8):1347-1354. doi: 10.2174/1871530320666200503052226.
Prediabetes, defined as impaired glucose tolerance and/or impaired fasting glucose, is a risk factor for future type 2 diabetes, dyslipidemia, cardiovascular disease and all-cause mortality. High serum levels of ischemia modified albumin (IMA) and malondialdehyde (MDA) as oxidative stress markers were determined in diabetes, however, no studies have investigated these markers together in prediabetes. The aim of the present study was to investigate the circulating levels of both IMA and MDA in a cohort of prediabetic adults. The possible associations between both markers and the atherogenic index of plasma (AIP) were also evaluated.
This study enrolled 100 adults with prediabetes and 50 healthy controls matched for age and sex. Anthropometric measurements, fasting and 2-hour post load glucose, glycosylated hemoglobin (A1c), lipids profile, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), high sensitivity C-reactive protein (hs-CRP), AIP, IMA and MDA were assessed.
IMA, MDA, hs-CRP and AIP were significantly higher in adults with prediabetes than in healthy controls. Male gender, fasting and post load glucose, A1c, fasting insulin, TGs, HDL-C, hs- CRP, AIP and MDA were independent predictor variables of IMA, whereas male gender, WC, fasting and post load glucose, A1c, fasting insulin, TC, TGs, LDL-C, HDL-C, hs-CRP and AIP were independent predictor variables of MDA.
The elevation of IMA concomitantly with MDA reflecting the antioxidant status in prediabetes, and their associations with hs-CRP and AIP should reinforce the idea of screening and treatment of prediabetes.
糖尿病前期定义为糖耐量受损和/或空腹血糖受损，是未来2型糖尿病、血脂异常、心血管疾病和全因死亡率的危险因素。糖尿病患者中已检测到作为氧化应激标志物的血清缺血修饰白蛋白（IMA）和丙二醛（MDA）水平升高，然而，尚无研究在糖尿病前期患者中同时研究这些标志物。本研究的目的是调查一组糖尿病前期成年人中IMA和MDA的循环水平。还评估了这两种标志物与血浆致动脉粥样硬化指数（AIP）之间的可能关联。
本研究纳入了100名糖尿病前期成年人和50名年龄和性别匹配的健康对照。评估了人体测量指标、空腹和餐后2小时血糖、糖化血红蛋白（A1c）、血脂谱、空腹胰岛素、胰岛素抵抗稳态模型评估（HOMA-IR）、高敏C反应蛋白（hs-CRP）、AIP、IMA和MDA。
糖尿病前期成年人的IMA、MDA、hs-CRP和AIP显著高于健康对照。男性、空腹和餐后血糖、A1c、空腹胰岛素、甘油三酯（TGs）、高密度脂蛋白胆固醇（HDL-C）、hs-CRP、AIP和MDA是IMA的独立预测变量，而男性、腰围（WC）、空腹和餐后血糖、A1c、空腹胰岛素、总胆固醇（TC）、TGs、低密度脂蛋白胆固醇（LDL-C）、HDL-C、hs-CRP和AIP是MDA的独立预测变量。
IMA与MDA同时升高反映了糖尿病前期的抗氧化状态，它们与hs-CRP和AIP的关联应强化对糖尿病前期进行筛查和治疗的理念。
