Department of Dermatology and Venereology, Ankara Numune Education and Research Hospital, Talatpaşa Street, No:44, Altındağ, 06100, Ankara, Turkey.
Department of Medical Biochemistry, Ankara Numune Training and Research Hospital, Ankara, Turkey.
Arch Dermatol Res. 2018 Dec;310(10):785-793. doi: 10.1007/s00403-018-1867-z. Epub 2018 Oct 6.
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. HS has been associated with obesity, adipokine imbalance, dyslipidemia, pro-inflammation, and metabolic syndrome (MS). The aim of this study was to determine the association between HS, and serum visfatin levels (SVLs), small-dense low-density lipoprotein cholesterol (sdLDL-C), and ischemia-modified albumin (IMA), as well as the association between HS, and smoking, alcohol consumption, anthropometric measurements, blood pressures (BPs), fasting blood glucose (FBG) and lipids, inflammatory markers, homocysteine, uric acid (UA), serum insulin levels (SILs), insulin resistance (IR) and MS, so as to identify relevant risk factors for HS. This case-control study included 40 patients (M/F: 23/17) and 40 age- and gender-matched controls (M/F: 23/17). Demographic data, smoking status and alcohol consumption, personal and family medical history, previous and current treatments were noted. Anthropometric data, BPs, FBG and lipids, homocysteine, UA, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and high-sensitivity CRP (hs-CRP), hemoglobin A1c (HbA1c), SILs, SVLs, IMA and sdLDL-C were measured. Homeostasis model assessment for IR (HOMA-IR) was calculated. The associations were made by univariate and multivariate analyses. Univariate analysis showed that there was a significant association between HS and smoking, pack-years of smoking, weight, body mass index (BMI), waist circumference (WC), triglycerides (TGs), high-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, SILs, CRP, hs-CRP, homocysteine, UA, ESR, HOMA-IR, SVLs, and MS. After adjusting for BMI and smoking status, the SVLs, SILs, and hs-CRP levels remained higher in the patients than in the controls (P = 0.02, P = 0.01, and P = 0.02, respectively). Multivariate analysis showed that there was a significant association between HS, and the SVLs and SILs, and smoking. Each unit increase in the SVL (P = 0.003, 95% CI 1.16-2.11) and SIL (P = 0.03, 95% CI 1.01-1.17) increased the risk of HS 1.56- and 1.09-fold, respectively. Furthermore, smoking was associated with a 14.87-fold increase in the risk of HS (P = 0.001, 95% CI 2.82-78.56). This study indicates that HS patients have higher SVLs, SILs, and hs-CRP levels than healthy controls-independent of BMI and smoking status. The SVL and SILs and smoking were independent risk factors for HS.
化脓性汗腺炎（HS）是一种慢性炎症性皮肤病。HS 与肥胖、脂联素失衡、血脂异常、促炎和代谢综合征（MS）有关。本研究旨在确定 HS 与血清内脏脂肪素水平（SVLs）、小而密低密度脂蛋白胆固醇（sdLDL-C）和缺血修饰白蛋白（IMA）之间的关系，以及 HS 与吸烟、饮酒、人体测量学指标、血压（BP）、空腹血糖（FBG）和血脂、炎症标志物、同型半胱氨酸、尿酸（UA）、血清胰岛素水平（SILs）、胰岛素抵抗（IR）和 MS 之间的关系，以确定 HS 的相关危险因素。这项病例对照研究纳入了 40 名患者（男/女：23/17）和 40 名年龄和性别匹配的对照组（男/女：23/17）。记录了人口统计学数据、吸烟状况和饮酒情况、个人和家族病史、既往和当前的治疗情况。测量了人体测量学数据、BP、FBG 和血脂、同型半胱氨酸、UA、红细胞沉降率（ESR）、C 反应蛋白（CRP）和高敏 C 反应蛋白（hs-CRP）、糖化血红蛋白（HbA1c）、SILs、SVLs、IMA 和 sdLDL-C。计算了胰岛素抵抗的稳态模型评估（HOMA-IR）。通过单变量和多变量分析进行了关联。单变量分析显示，HS 与吸烟、吸烟包年数、体重、体重指数（BMI）、腰围（WC）、甘油三酯（TGs）、高密度脂蛋白胆固醇、极低密度脂蛋白胆固醇、SILs、CRP、hs-CRP、同型半胱氨酸、UA、ESR、HOMA-IR、SVLs 和 MS 之间存在显著关联。在调整 BMI 和吸烟状况后，患者的 SVLs、SILs 和 hs-CRP 水平仍高于对照组（P=0.02、P=0.01 和 P=0.02）。多变量分析显示，HS 与 SVLs 和 SILs 以及吸烟之间存在显著关联。SVL 每增加一个单位（P=0.003，95%CI 1.16-2.11）和 SIL （P=0.03，95%CI 1.01-1.17）使 HS 的风险分别增加 1.56 倍和 1.09 倍。此外，吸烟使 HS 的风险增加 14.87 倍（P=0.001，95%CI 2.82-78.56）。本研究表明，与健康对照组相比，HS 患者的 SVLs、SILs 和 hs-CRP 水平更高，独立于 BMI 和吸烟状况。SVL 和 SILs 和吸烟是 HS 的独立危险因素。
