载脂蛋白相关指数与不稳定型心绞痛合并糖尿病前期患者心血管结局的关系。
The relation between atherogenic index of plasma and cardiovascular outcomes in prediabetic individuals with unstable angina pectoris.
机构信息
Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Clinical Center for Coronary Heart Disease, Department of Cardiology, Beijing Anzhen Hospital, Beijing Institute of Heart Lung and Blood Vessel Disease, Capital Medical University, Beijing, China.
Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
出版信息
BMC Endocr Disord. 2023 Aug 31;23(1):187. doi: 10.1186/s12902-023-01443-x.
BACKGROUND
The atherogenic index of plasma (AIP) is a novel biomarker associated with atherosclerosis, and an important risk factor for atherosclerosis, but its relation with cardiovascular prognosis in prediabetic patients with unstable angina pectoris (UAP) is still uncertain.
METHODS
This study included 1096 prediabetic patients with UAP who were subjected to follow-up for a maximum of 30 months, with cardiac death, refractory angina, and non-fatal myocardial infarction (MI) being the primary cardiovascular endpoints.
RESULTS
A significantly increased AIP was observed for the group with primary cardiovascular endpoints. Kaplan-Meier curves corresponding to these endpoints revealed pronounced differences between these two AIP groups (Log-rank P < 0.001). Multivariate Cox proportional hazards analyses highlighted AIP as being independent related to this primary endpoint (HR 1.308, 95% CI: 1.213-1.412, P < 0.001). AIP addition to the baseline risk model improved the prediction of the primary endpoint (AUC: baseline model, 0.622, vs. baseline model + AIP, 0.739, P < 0.001).
CONCLUSIONS
AIP could be used to predict cardiovascular events in prediabetic individuals with UAP.
背景
血浆致动脉粥样硬化指数（AIP）是一种与动脉粥样硬化相关的新型生物标志物，也是动脉粥样硬化的一个重要危险因素，但它与不稳定型心绞痛（UAP）合并糖尿病前期患者的心血管预后的关系尚不确定。
方法
本研究纳入了 1096 例 UAP 合并糖尿病前期患者，对其进行了最长 30 个月的随访，主要心血管终点为心脏死亡、难治性心绞痛和非致死性心肌梗死（MI）。
结果
主要心血管终点组的 AIP 显著升高。这些终点对应的 Kaplan-Meier 曲线显示这两组 AIP 之间存在明显差异（Log-rank P<0.001）。多变量 Cox 比例风险分析强调 AIP 与该主要终点独立相关（HR 1.308，95%CI：1.213-1.412，P<0.001）。AIP 增加到基线风险模型中提高了对主要终点的预测（AUC：基线模型为 0.622，基线模型+AIP 为 0.739，P<0.001）。
结论
AIP 可用于预测 UAP 合并糖尿病前期患者的心血管事件。
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