Department of Neuroscience, Genentech, Inc., South San Francisco, CA 94080, USA.
Department of Immunology, Genentech, Inc., South San Francisco, CA 94080, USA.
Cell. 2020 Apr 30;181(3):517-519. doi: 10.1016/j.cell.2020.03.060.
Some children with autism spectrum disorder (ASD) show behavioral improvements when experiencing inflammation accompanied by fever; however, little is known about the mechanisms that underlie these beneficial effects. In a recent issue of Nature, Reed and colleagues demonstrate that the production of interleukin-17 (IL-17) during inflammation promotes social behavior in mouse models of neurodevelopmental disorders.
一些自闭症谱系障碍（ASD）儿童在经历伴有发热的炎症时表现出行为改善，但人们对这些有益影响的潜在机制知之甚少。在最近一期的《自然》杂志上，里德及其同事证明，在神经发育障碍的小鼠模型中，炎症期间白细胞介素 17（IL-17）的产生促进了社交行为。
