利什曼原虫：巨噬细胞焦亡体中表观遗传调控的大师。
Leishmania: A Maestro in Epigenetic Manipulation of Macrophage Inflammasomes.
机构信息
Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
出版信息
Trends Parasitol. 2020 Jun;36(6):498-501. doi: 10.1016/j.pt.2020.04.008. Epub 2020 Apr 28.
Epigenetic manipulation of host cells by intracellular pathogens has become increasingly evident. Lecoeur et al. show us how Leishmania amazonensis inhibits macrophage inflammasomes by modifying histone H3 activation marks on NF-κB-associated gene promoters that increase the expression of inhibitors and downmodulates activators of this pathway.
胞内病原体对宿主细胞的表观遗传修饰作用日益明显。Lecoeur 等人向我们展示了美洲钩端螺旋体如何通过修饰与 NF-κB 相关基因启动子上的组蛋白 H3 激活标记来抑制巨噬细胞炎性小体，从而增加该途径抑制剂的表达并下调其激活剂。
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