谷胱甘肽 S-转移酶 M1 和 T1 缺失对北非人群帕金森病风险的影响。
Effects of glutathione S-transferase M1 and T1 deletions on Parkinson's disease risk among a North African population.
机构信息
Metabolic Biophysics and Applied Pharmacology, Laboratory, Department of Biophysics, Faculty of Medicine Sousse, Sousse University, Sousse 4002, Tunisia; Faculty of Physical and Natural Mathematical Sciences of Tunis, University of Tunis El Manar, Tunis 2092, Tunisia.
Metabolic Biophysics and Applied Pharmacology, Laboratory, Department of Biophysics, Faculty of Medicine Sousse, Sousse University, Sousse 4002, Tunisia.
出版信息
Rev Neurol (Paris). 2021 Mar;177(3):290-295. doi: 10.1016/j.neurol.2020.03.013. Epub 2020 Apr 29.
PURPOSE
In this study, the effects of glutathione S-transferase polymorphisms Mu1 (GSTM1) and glutathione S-transferase polymorphisms Theta1 (GSTT1) on Parkinson's disease (PD) risk factor were evaluated in a Tunisian population.
METHODS
These polymorphisms were analyzed in 229 healthy Tunisian subjects and 64 Tunisian patients with PD, using a polymerase chain reaction (PCR). Statistical analysis was performed using SPSS 18.0. The relative associations between the GST genotypes and PD were assessed by calculating the odds ratios (ORs) and 95% confidence intervals (CIs).
RESULTS
The study results demonstrated that the individuals with GSTM1 [OR=3.93, 95% CI: 1.98-7.92, P=10] and GSTT1 [OR=5.45, 95% CI: 2.90-10.30, p=10] were statistically associated with the risk of PD. A significant association was also found between the individuals with both GSTM1/T1 null genotypes and PD risk [OR=22.10, 95% CI: 6.99-73.75, P=10].
CONCLUSION
These genotyping findings suggest that the absence of both GSTM1 and GSTT1 activity could be a contributory factor for the development of PD.
目的
本研究旨在评估谷胱甘肽 S-转移酶 Mu1（GSTM1）和谷胱甘肽 S-转移酶 Theta1（GSTT1）多态性对突尼斯人群帕金森病（PD）风险因素的影响。
方法
采用聚合酶链反应（PCR）技术，在 229 名健康突尼斯受试者和 64 名突尼斯 PD 患者中分析了这些多态性。使用 SPSS 18.0 进行统计分析。通过计算比值比（ORs）和 95%置信区间（CIs），评估 GST 基因型与 PD 之间的相对关联。
结果
研究结果表明，GSTM1[OR=3.93，95%CI：1.98-7.92，P=10]和 GSTT1[OR=5.45，95%CI：2.90-10.30，p=10]缺失的个体与 PD 风险具有统计学关联。同时，GSTM1/T1 双缺失基因型个体与 PD 风险之间也存在显著关联[OR=22.10，95%CI：6.99-73.75，P=10]。
结论
这些基因分型结果表明，GSTM1 和 GSTT1 活性缺失可能是 PD 发生的一个促成因素。
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