1H-nmr analysis of herbimycins and dihydro-herbimycins.

作者信息

Lin L Z, Blaskó G, Cordell G A

机构信息

Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois, Chicago 60612.

出版信息

J Nat Prod. 1988 Nov-Dec;51(6):1161-5. doi: 10.1021/np50060a018.

DOI:10.1021/np50060a018

PMID:3236008

Abstract

Herbimycin A [1] and herbimycin C [3] and their dihydro-derivatives 5 and 6, respectively, have been obtained from the cell broth of Streptomyces hygroscopicus, and the assignment of their 1H-nmr has been completed. Strong cytotoxic activity of antibiotics 1, 3, 5, and 6 against the P-388 and KB lymphocytic leukemia test systems has been demonstrated.

摘要