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Two herbimycin analogs, 4,5-dihydro-(4S)-4-hydroxyherbimycin B and (15S)-15-hydroxyherbimycin B, from Streptomyces sp. CPCC 200291.

作者信息

Zhao Wei, Jiang Bingya, Wu Linzhuan, Nan Yanni, Cui Jing, Yu Liyan, Wei Yuzhen, Li Jinghua, Shan Guangzhi

机构信息

Key Laboratory of Biotechnology of Antibiotics of Ministry of Health, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

出版信息

J Antibiot (Tokyo). 2015 Jul;68(7):476-80. doi: 10.1038/ja.2015.12. Epub 2015 Feb 18.

DOI:10.1038/ja.2015.12
PMID:25690359
Abstract
摘要

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1
Two herbimycin analogs, 4,5-dihydro-(4S)-4-hydroxyherbimycin B and (15S)-15-hydroxyherbimycin B, from Streptomyces sp. CPCC 200291.来自链霉菌CPCC 200291的两种除草霉素类似物,4,5-二氢-(4S)-4-羟基除草霉素B和(15S)-15-羟基除草霉素B。
J Antibiot (Tokyo). 2015 Jul;68(7):476-80. doi: 10.1038/ja.2015.12. Epub 2015 Feb 18.
2
TMC-135A and B, new triene-ansamycins, produced by Streptomyces sp.链霉菌属产生的新型三烯安莎霉素TMC - 135A和B
J Antibiot (Tokyo). 2000 Jul;53(7):724-7. doi: 10.7164/antibiotics.53.724.
3
SAR study of a novel triene-ansamycin group compound, quinotrierixin, and related compounds, as inhibitors of ER stress-induced XBP1 activation.新型三烯-安莎霉素类化合物喹诺三萜灵及相关化合物作为内质网应激诱导的XBP1激活抑制剂的构效关系研究
J Antibiot (Tokyo). 2008 May;61(5):312-7. doi: 10.1038/ja.2008.44.
4
1H-nmr analysis of herbimycins and dihydro-herbimycins.
J Nat Prod. 1988 Nov-Dec;51(6):1161-5. doi: 10.1021/np50060a018.
5
Herbimycins D-F, ansamycin analogues from Streptomyces sp. RM-7-15.从链霉菌 RM-7-15 中分离得到的 ansamycin 类似物 Herbimycins D-F。
J Nat Prod. 2013 Sep 27;76(9):1619-26. doi: 10.1021/np400308w. Epub 2013 Aug 15.
6
SAR study of a novel triene-ansamycin group compound, quinotrierixin, and related compounds, as inhibitors of ER stress-induced XBP1 activation.新型三烯-安莎霉素类化合物喹诺三嗪及其相关化合物作为内质网应激诱导的XBP1激活抑制剂的构效关系研究
J Antibiot (Tokyo). 2008 May;61(5):303-11. doi: 10.1038/ja.2008.43.
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Ansamycin antibiotics as free radical scavengers isolated from Streptomyces by using the bactericidal action of the hydroxyl radical.通过利用羟基自由基的杀菌作用从链霉菌中分离出的作为自由基清除剂的安莎霉素类抗生素。
Biosci Biotechnol Biochem. 1996 Sep;60(9):1507-9. doi: 10.1271/bbb.60.1507.
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New ansamycin derivatives generated by simultaneous mutasynthesis.同时突变合成产生的新型安莎霉素衍生物。
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本文引用的文献

1
Herbimycins D-F, ansamycin analogues from Streptomyces sp. RM-7-15.从链霉菌 RM-7-15 中分离得到的 ansamycin 类似物 Herbimycins D-F。
J Nat Prod. 2013 Sep 27;76(9):1619-26. doi: 10.1021/np400308w. Epub 2013 Aug 15.
2
Methanethiol as a catabolite of methionine provides methylthio- group for chemical formation of 19-S-methylgeldanamycin and 17,19-dimethylthioherbimycin A.甲硫醇作为蛋氨酸的一种分解代谢产物,为19 - S -甲基格尔德霉素和17,19 - 二甲基硫代除草霉素A的化学合成提供甲硫基。
J Antibiot (Tokyo). 2013 Aug;66(8):499-503. doi: 10.1038/ja.2013.31. Epub 2013 Apr 17.
3
Identification of 4,5-dihydro-4-hydroxygeldanamycins as shunt products of geldanamycin biosynthesis.
鉴定出 4,5-二氢-4-羟基格尔德霉素是格尔德霉素生物合成的分流产物。
J Nat Prod. 2012 Aug 24;75(8):1480-4. doi: 10.1021/np3001738. Epub 2012 Jul 31.
4
Thiazinogeldanamycin, a new geldanamycin derivative produced by Streptomyces hygroscopicus 17997.噻嗪酮型格尔德霉素,吸水链霉菌 17997 产生的一种新型格尔德霉素衍生物。
J Microbiol Biotechnol. 2011 Jun;21(6):599-603.
5
Insights into the biosynthesis of the benzoquinone ansamycins geldanamycin and herbimycin, obtained by gene sequencing and disruption.通过基因测序和破坏获得的对苯醌安莎霉素格尔德霉素和赫比霉素生物合成的见解。
Appl Environ Microbiol. 2005 Aug;71(8):4862-71. doi: 10.1128/AEM.71.8.4862-4871.2005.
6
Production of 8-demethylgeldanamycin and 4,5-epoxy-8-demethylgeldanamycin from a recombinant strain of Streptomyces hygroscopicus.从吸水链霉菌重组菌株生产8-去甲基格尔德霉素和4,5-环氧-8-去甲基格尔德霉素。
J Nat Prod. 2005 Apr;68(4):607-10. doi: 10.1021/np0496744.
7
Intracellular retention and degradation of the epidermal growth factor receptor, two distinct processes mediated by benzoquinone ansamycins.表皮生长因子受体的细胞内滞留与降解,由苯醌安莎霉素介导的两个不同过程。
J Biol Chem. 2000 Jul 21;275(29):21850-5. doi: 10.1074/jbc.M001834200.
8
The hsp90-based chaperone system: involvement in signal transduction from a variety of hormone and growth factor receptors.基于热休克蛋白90的伴侣蛋白系统:参与多种激素和生长因子受体的信号转导。
Proc Soc Exp Biol Med. 1998 Apr;217(4):420-34. doi: 10.3181/00379727-217-44252.
9
Herbimycin B, a new benzoquinonoid ansamycin with anti-TMV and herbicidal activities.除莠霉素B,一种具有抗烟草花叶病毒和除草活性的新型苯醌类安莎霉素。
J Antibiot (Tokyo). 1980 Oct;33(10):1114-9. doi: 10.7164/antibiotics.33.1114.
10
Chemical modification and antitumor activity of herbimycin A. 8,9-Epoxide, 7,9-cyclic carbamate, and 17 or 19-amino derivatives.
J Antibiot (Tokyo). 1984 Oct;37(10):1264-7. doi: 10.7164/antibiotics.37.1264.