Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California, USA; Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California, USA; Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Am J Ophthalmol. 2021 Feb;222:302-309. doi: 10.1016/j.ajo.2020.04.018. Epub 2020 Apr 28.
To evaluate the correlation between choriocapillaris (CC) flow alterations and scotopic macular sensitivity (sMS) in patients with early and intermediate age-related macular degeneration (AMD).
Prospective cross-sectional study.
We acquired 2 3 × 3 mm and 2 6 × 6 mm swept-source optical coherence tomography angiography (OCTA) images of 1 eye of consecutive early or intermediate AMD patients at the Doheny UCLA Eye Centers. After 30 minutes of dark adaptation, the same eye underwent scotopic microperimetry with an 18-degree-wide grid (52 stimuli) centered on the fovea. The 2 en face CC angiograms obtained from each scan pattern were compensated for signal loss and averaged. The main outcome measures were correlation between percentages of flow deficits (FD and FD) and sMS in the central 10° (MS) and the overall pattern (MS).
Thirty eyes of 30 patients were enrolled, with 14 (46.7%) having subretinal drusenoid deposits (SDD). In the averaged OCTA scans, the FD was 12.56% ± 2.41% while the FD was 9.33% ± 1.84%. The mean MS and MS were 13.84 ± 5.89 dB and 14.64 ± 5.21 dB, respectively. For the MS the multivariate regression analysis showed a significant association only with FD (β: -0.628, P < .001) while the MS was significantly correlated with both SDD (β: -0.32, P = .047) and FD (β: -0.473, P = .005).
Our study reports a significant correlation between the CC flow impairment and the sMS in eyes with early or intermediate AMD. If replicated in future longitudinal studies, the choriocapillaris FD may prove to be a useful parameter for evaluating the functional status and prognosis of these eyes.
评估脉络膜毛细血管（CC）血流改变与早中期年龄相关性黄斑变性（AMD）患者暗适应黄斑敏感性（sMS）之间的相关性。
前瞻性横断面研究。
我们在 Doheny UCLA 眼科中心连续采集了 30 只早期或中期 AMD 患者 1 只眼的 2 个 3×3mm 和 2 个 6×6mm 扫频源光学相干断层扫描血管造影（OCTA）图像。暗适应 30 分钟后，同一只眼接受以黄斑为中心的 18 度宽网格（52 个刺激）的暗适应微视野检查。从每个扫描模式获得的 2 个面内 CC 血管造影图进行信号丢失补偿并平均化。主要观察指标为中央 10°（MS）和整体模式（MS）中血流缺损（FD 和 FD）百分比与 sMS 的相关性。
共纳入 30 只眼 30 例患者，其中 14 只（46.7%）有视网膜下类脂沉积（SDD）。在平均 OCTA 扫描中，FD 为 12.56%±2.41%，FD 为 9.33%±1.84%。平均 MS 和 MS 分别为 13.84±5.89dB 和 14.64±5.21dB。对于 MS，多元回归分析仅显示与 FD 显著相关（β：-0.628，P<.001），而 MS 与 SDD（β：-0.32，P=.047）和 FD（β：-0.473，P=.005）均显著相关。
本研究报告了早中期 AMD 患者脉络膜毛细血管血流损伤与 sMS 之间存在显著相关性。如果在未来的纵向研究中得到复制，脉络膜毛细血管 FD 可能被证明是评估这些眼睛功能状态和预后的有用参数。
