Solid-state nuclear magnetic resonance studies of nanoparticles.

In this trends article, we review seminal and recent studies using static and magic-angle spinning solid-state NMR to study the structure of nanoparticles and ligands attached to nanoparticles. Solid-state NMR techniques including one-dimensional multinuclear NMR, cross-polarization, techniques for measuring dipolar coupling and internuclear distances, and multidimensional NMR have provided insight into the core-shell structure of nanoparticles as well as the structure of ligands on the nanoparticle surface. Hyperpolarization techniques, in particular solid-state dynamic nuclear polarization (DNP), have enabled detailed studies of nanoparticle core-shell structure and surface chemistry, by allowing unprecedented levels of sensitivity to be achieved. The high signal-to-noise afforded by DNP has allowed homonuclear and heteronuclear correlation experiments involving nuclei with low natural abundance to be performed in reasonable experimental times, which previously would not have been possible. The use of DNP to study nanoparticles and their applications will be a fruitful area of study in the coming years as well.