Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang, PR China.
School of Nursing, China Medical University, Shenyang, China.
J Surg Res. 2020 Sep;253:156-166. doi: 10.1016/j.jss.2020.03.032. Epub 2020 Apr 30.
Most studies revealed that microRNAs could play important roles in the development of various types of cancers. However, the findings remain inconsistent and controversial. To get more accurate results about the association of miR-26a-1 rs7372209 and miR-423 rs6505162 polymorphisms with risk of cancer, we conduct this meta-analysis.
We have searched relevant articles from the PubMed, Web of Science, Wanfang, and Chinese National Knowledge Infrastructure databases up to May 3, 2019. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were analyzed to assess the relationship between these two genetic polymorphisms and susceptibility to cancer. All statistical analyses were performed with Stata 12.0 software.
Thirty-five articles were eligible in this meta-analysis, including 17,746 cases and 21,808 controls. Our results suggested that the miR-26a-1 rs7372209 polymorphism was associated with the susceptibility to overall cancer significantly in homozygote comparison and recessive model (TT versus CC: OR = 1.167, 95% CI: 1.025-1.329, P = 0.020; TT versus CT + CC: OR = 1.162, 95% CI: 1.025-1.318, P = 0.019). For miR-423 rs6505162, this study showed that the relationship between it and overall cancer susceptibility was statistically significant among five genetic models (CA versus CC: OR = 0.884, 95% CI: 0.806-0.969, P = 0.009; AA + CA versus CC: OR = 0.870, 95% CI: 0.789-0.959, P = 0.005; AA versus CA + CC: OR = 0.904, 95% CI: 0.827-0.988, P = 0.026; A versus C: OR = 0.899, 95% CI: 0.834-0.970, P = 0.006) rather than homozygote model.
Rs7372209 in miR-26a-1 and rs6505162 in miR-423 are associated with overall cancer susceptibility.
大多数研究表明，miRNAs 在各种类型癌症的发生发展中可能发挥着重要作用。然而，目前的研究结果仍存在不一致和争议。为了获得关于 miR-26a-1 rs7372209 和 miR-423 rs6505162 多态性与癌症风险关联的更准确结果，我们进行了这项荟萃分析。
我们检索了PubMed、Web of Science、万方和中国知网数据库中截至 2019 年 5 月 3 日的相关文献。采用合并优势比（OR）和 95%置信区间（CI）来评估这两种遗传多态性与癌症易感性之间的关系。所有统计分析均采用 Stata 12.0 软件进行。
本荟萃分析共纳入 35 篇文献，包括 17746 例病例和 21808 例对照。结果显示，miR-26a-1 rs7372209 多态性在同合子比较和隐性模型中与总体癌症易感性显著相关（TT 与 CC：OR=1.167，95%CI：1.025-1.329，P=0.020；TT 与 CT+CC：OR=1.162，95%CI：1.025-1.318，P=0.019）。对于 miR-423 rs6505162，本研究表明，在 5 种遗传模型中，它与总体癌症易感性之间的关系具有统计学意义（CA 与 CC：OR=0.884，95%CI：0.806-0.969，P=0.009；AA+CA 与 CC：OR=0.870，95%CI：0.789-0.959，P=0.005；AA 与 CA+CC：OR=0.904，95%CI：0.827-0.988，P=0.026；A 与 C：OR=0.899，95%CI：0.834-0.970，P=0.006），而非同合子模型。
miR-26a-1 中的 rs7372209 和 miR-423 中的 rs6505162 与总体癌症易感性相关。
