Department of Neurology, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, NG7 2UH, UK.
Department of Neurology, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, NG7 2UH, UK.
Mult Scler Relat Disord. 2020 Jul;42:102074. doi: 10.1016/j.msard.2020.102074. Epub 2020 Apr 26.
The clinical spectrum of myelin oligodendrocyte glycoprotein (MOG)-antibody-associated disease is expanding.
To describe an unusual case of MOG-antibody-associated hypertrophic pachymeningitis (HP).
Case study.
A 57-year-old female presented with a generalised seizure on a background of 3 months history of progressive cognitive decline and behavioural changes. Brain Magnetic Resonance Imaging (MRI) revealed widespread pachymeningeal enhancement and hyperintense signal in both hippocampi. Cerebrospinal Fluid (CSF) examination was normal. The patient was found positive for MOG-antibody. She clinically improved with steroids and the MRI abnormalities completely resolved.
Clinicians might consider testing for MOG-antibody in cases with HP.
髓鞘少突胶质细胞糖蛋白 (MOG)-抗体相关疾病的临床表现正在不断扩展。
描述一例不常见的 MOG-抗体相关肥厚性硬脑膜炎 (HP)。
病例研究。
一名 57 岁女性，在认知功能进行性下降和行为改变 3 个月的基础上出现全身发作性癫痫。脑部磁共振成像 (MRI) 显示广泛的硬脑膜增强和双侧海马高信号。脑脊液 (CSF) 检查正常。该患者 MOG-抗体检测阳性。她接受类固醇治疗后临床症状改善，MRI 异常完全缓解。
对于 HP 患者，临床医生可能会考虑检测 MOG-抗体。
