Kluth D, Lambrecht W, Reich P
Department of Surgery, University Hospital, Hamburg, Germany.
J Pediatr Surg. 1988 Dec;23(12):1095-101. doi: 10.1016/s0022-3468(88)80322-1.
Most researchers believe that hypospadias arises from malformation of the penile urethra. However, this concept has been recently rejected, and it has been suggested that the opening of the urethra is "pushed forward" by growth of the perineum. In order to obtain more information on the development of the urethra, late stages of phallic development were studied in 220 rat embryos with scanning electron microscopy (SEM). In our study, signs of rupture of the urogenital membrane or fusion of the urethral folds could not be found. Therefore, we could not confirm the traditional concept for the development of the phallic urethra. A new concept of urethral development is suggested and the pathogenesis of hypospadias is discussed.
大多数研究人员认为，尿道下裂源于阴茎尿道的畸形。然而，这一概念最近遭到了否定，有人提出尿道开口是被会阴的生长“向前推移”的。为了获取更多有关尿道发育的信息，我们用扫描电子显微镜（SEM）对220只大鼠胚胎的阴茎发育后期进行了研究。在我们的研究中，未发现尿生殖膜破裂或尿道褶融合的迹象。因此，我们无法证实阴茎尿道发育的传统概念。本文提出了一个尿道发育的新概念，并对尿道下裂的发病机制进行了讨论。
