Kluth Dietrich, Fiegel Henning C, Geyer Christian, Metzger Roman
Department of Pediatric Surgery, University of Leipzig, Leipzig, Germany.
Semin Pediatr Surg. 2011 Aug;20(3):176-87. doi: 10.1053/j.sempedsurg.2011.03.003.
Faulty ventral openings of the urethra constitute a broad spectrum of malformations that are subsumed under the term "hypospadia." The normal development of the urethra and the genitals critically depends on the following events: (a) formation of the external genitalia, (b) fate of the cloacal membrane, and (c) formation of the distal urethra. The purpose of this study was to demonstrate these events using microsurgical techniques and scanning electron microscopy in staged rat embryos.
尿道腹侧开口异常构成了一系列广泛的畸形，这些畸形被归入“尿道下裂”这一术语之下。尿道和生殖器的正常发育关键取决于以下事件：(a) 外生殖器的形成，(b) 泄殖腔膜的命运，以及 (c) 远端尿道的形成。本研究的目的是使用显微外科技术和扫描电子显微镜在分期的大鼠胚胎中展示这些事件。
