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一项探索性临床研究评估了经冠向推进瓣用于单个牙龈退缩治疗的容积稳定胶原基质的安全性和性能。

An exploratory clinical study evaluating safety and performance of a volume-stable collagen matrix with coronally advanced flap for single gingival recession treatment.

机构信息

Department of Biomedical and Neuromotor Sciences, University of Bologna, Via San Vitale 59, Bologna, Italy.

Department of Periodontics & Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA.

出版信息

Clin Oral Investig. 2020 Sep;24(9):3181-3191. doi: 10.1007/s00784-019-03192-5. Epub 2020 May 2.

DOI:10.1007/s00784-019-03192-5
PMID:32361892
Abstract

OBJECTIVE

To test the safety of a new volume-stable collagen matrix (VCMX) in combination with coronally advanced flap (CAF) for the treatment of single gingival recession.

MATERIAL AND METHODS

Ten patients were treated for single RT1 gingival recession. Complete and mean root coverage, gingival thickness and keratinized tissue height, patient-reported outcome measures (PROMs), and safety were assessed up to 180 days. Descriptive statistics were used to analyze the clinical parameters.

RESULTS

VCMX resulted to be safe with no serious adverse events in all patients. At 6 months, root coverage was 96.7% with 90% of defects exhibiting complete coverage. There was an increase in mean width of keratinized tissue (KT) (0.4 ± 0.8 mm) and in gingival thickness (GT) (0.4 ± 0.34 mm); however, the difference was not statistically significant compared to baseline parameters. Pain perception and pain-killer consumption were low and decreasing further at 7 days. Esthetic satisfaction for both patients and experts revealed excellent scores.

CONCLUSIONS

VCMX is a safe and well-tolerated device for the treatment of single gingival recessions. In combination with CAF, it resulted in a high performance in terms of mean and complete root coverage, KT width, and GT increase. VCMX may reduce patient discomfort and post-operative morbidity.

CLINICAL RELEVANCE

VCMX is a safe and stable substitute for the treatment of gingival recession in conjunction with coronally advanced technique.

摘要

目的

测试新型体积稳定型胶原基质(VCMX)联合冠向推进瓣(CAF)治疗单个牙龈退缩的安全性。

材料和方法

10 名患者接受了单个 RT1 牙龈退缩的治疗。在 180 天内评估了完全和平均根覆盖、牙龈厚度和角化组织高度、患者报告的结果测量(PROM)以及安全性。使用描述性统计分析临床参数。

结果

所有患者均未出现严重不良事件,表明 VCMX 是安全的。6 个月时,根覆盖为 96.7%,90%的缺损表现为完全覆盖。角化组织(KT)的平均宽度(0.4±0.8mm)和牙龈厚度(GT)(0.4±0.34mm)均有所增加;然而,与基线参数相比,差异无统计学意义。疼痛感知和止痛药的使用量较低,并在 7 天时进一步下降。患者和专家对美观满意度均为优秀评分。

结论

VCMX 是一种安全且耐受良好的治疗单个牙龈退缩的设备。与 CAF 联合使用,在平均和完全根覆盖、KT 宽度和 GT 增加方面表现出了优异的性能。VCMX 可能会减少患者的不适和术后发病率。

临床相关性

VCMX 是一种安全且稳定的替代物,可与冠向推进技术联合治疗牙龈退缩。

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1
Influence of tooth location on coronally advanced flap procedures for root coverage.牙位对根向复位瓣术进行根面覆盖的影响。
J Periodontol. 2018 Dec;89(12):1428-1441. doi: 10.1002/JPER.18-0201. Epub 2018 Aug 10.
2
Decision making in root-coverage procedures for the esthetic outcome.审美效果的根覆盖程序中的决策制定。
Periodontol 2000. 2018 Jun;77(1):54-64. doi: 10.1111/prd.12205. Epub 2018 Mar 4.
3
Coronally Advanced Flap with Site-Specific Application of Connective Tissue Graft for the Treatment of Multiple Adjacent Gingival Recessions: A 3-Year Follow-Up Case Series.
3D-Analysis of Peri-Implant Soft Tissue Gain With Collagen Matrix and Connective Tissue Graft: A Randomized Control Trial.
胶原蛋白基质与结缔组织移植用于种植体周围软组织增量的三维分析:一项随机对照试验
Clin Implant Dent Relat Res. 2025 Apr;27(2):e70043. doi: 10.1111/cid.70043.
4
Autologous platelet concentrates in root coverage procedures.牙根覆盖手术中的自体富血小板浓缩物
Periodontol 2000. 2025 Feb;97(1):215-235. doi: 10.1111/prd.12614. Epub 2024 Oct 15.
5
Adjunctive use of hyaluronic acid in the treatment of gingival recessions: a systematic review and meta-analysis.透明质酸在治疗牙龈退缩中的辅助应用:系统评价和荟萃分析。
Clin Oral Investig. 2024 May 21;28(6):329. doi: 10.1007/s00784-024-05701-7.
6
Comparison of the efficacy and long-term stability of tunnel technique and coronally advanced flap in the treatment of gingival recession: a Meta-analysis.隧道技术与冠向复位瓣术治疗牙龈退缩的疗效及长期稳定性比较:Meta 分析。
Hua Xi Kou Qiang Yi Xue Za Zhi. 2023 Aug 1;41(4):450-462. doi: 10.7518/hxkq.2023.2023045.
7
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Case Rep Dent. 2023 Mar 22;2023:3929269. doi: 10.1155/2023/3929269. eCollection 2023.
8
Effectiveness of Plasma-Rich Fibrin and De-Epithelialized Free Gingival Graft in the Treatment of Gingival Recessions.富血小板纤维蛋白和去上皮化游离龈瓣移植治疗牙龈退缩的疗效。
Medicina (Kaunas). 2023 Feb 23;59(3):447. doi: 10.3390/medicina59030447.
9
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J Periodontal Implant Sci. 2022 Dec;52(6):466-478. doi: 10.5051/jpis.2105760288. Epub 2022 Jul 27.
10
Recombinant human platelet-derived growth factor improves root coverage of a collagen matrix for multiple adjacent gingival recessions: A triple-blinded, randomized, placebo-controlled trial.重组人血小板衍生生长因子改善胶原基质对多个相邻牙龈退缩的根覆盖:一项三盲、随机、安慰剂对照试验。
J Clin Periodontol. 2022 Nov;49(11):1169-1184. doi: 10.1111/jcpe.13706. Epub 2022 Jul 31.
采用结缔组织移植位点特异性应用的冠向推进瓣治疗多个相邻牙龈退缩:一项3年随访病例系列研究
Int J Periodontics Restorative Dent. 2018 Jan/Feb;38(1):25-33. doi: 10.11607/prd.3438.
4
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J Clin Periodontol. 2018 Jan;45(1):78-88. doi: 10.1111/jcpe.12834. Epub 2017 Nov 21.
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Long-Term Stability of Root Coverage by Coronally Advanced Flap Procedures.冠向推进瓣术式对根面覆盖的长期稳定性。
J Periodontol. 2017 Jul;88(7):626-633. doi: 10.1902/jop.2017.160767. Epub 2017 Mar 17.
6
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7
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J Clin Periodontol. 2016 Oct;43(10):874-85. doi: 10.1111/jcpe.12588. Epub 2016 Aug 12.
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J Clin Periodontol. 2014 Nov;41(11):1098-107. doi: 10.1111/jcpe.12303. Epub 2014 Sep 22.
10
Efficacy of periodontal plastic surgery procedures in the treatment of localized facial gingival recessions. A systematic review.牙周整形手术治疗局限性面部牙龈退缩的疗效。系统评价。
J Clin Periodontol. 2014 Apr;41 Suppl 15:S44-62. doi: 10.1111/jcpe.12182.