Khavinson V K, Linkova N S, Diatlova A S, Gutop E O, Orlova O A
Saint-Petersburg Institute of Bioregulation and Gerontology, 3 pr. Dinamo, St. Petersburg 197110, Russian Federation, e-mail:
I.P.Pavlov Institute of Physiology, 6 Makarova emb., St. Petersburg 199034, Russian Federation.
Adv Gerontol. 2020;33(1):46-54.
Short peptides are applied for supporting skin function during ageing, because they can permeate the intact stratum corneum of the epidermis and affect the cells of the dermis. Short peptides are part of natural metabolism of cells and many of them have geroprotective properties. In the review we are considering the base sorts of peptides that are used for normalized skin fibroblasts function: matrikines, carnosine, collagen peptides, cytokine and growth factor analogs, defensins, immunoprotective peptides and polyfunctional peptides. Polyfunctional peptides (AcSDKP, KED, AEDG, AED) have geroprotective properties, slow apoptosis and stimulate skin cell proliferation, also increase functional activity of skin fibroblasts, normalize intracellular matrix hemostasis. Polyfunctional peptides are the antioxidants and immunoprotectors and can activate microcirculation in dermis. Peptide regulation of skin function during ageing are the fast-developing and prospective area in molecular gerontology.
短肽被应用于在衰老过程中支持皮肤功能，因为它们能够渗透完整的表皮角质层并影响真皮细胞。短肽是细胞自然代谢的一部分，其中许多具有老年保护特性。在这篇综述中，我们将探讨用于使皮肤成纤维细胞功能正常化的各类基础肽：基质细胞衍生因子、肌肽、胶原蛋白肽、细胞因子和生长因子类似物、防御素、免疫保护肽和多功能肽。多功能肽（AcSDKP、KED、AEDG、AED）具有老年保护特性，减缓细胞凋亡并刺激皮肤细胞增殖，还能增加皮肤成纤维细胞的功能活性，使细胞内基质稳态正常化。多功能肽是抗氧化剂和免疫保护剂，能够激活真皮中的微循环。衰老过程中肽对皮肤功能调节是分子老年学中快速发展且具有前景的领域。
