Agrawal Y K, Prakasam K
Faculty of Technology and Engineering, M.S. University of Baroda, India.
J Pharm Sci. 1988 Oct;77(10):885-8. doi: 10.1002/jps.2600771015.
Five batches of sulfamethoxazole tablets were prepared using different binders [starch, acacia, ethyl cellulose sodium carboxymethylcellulose, and povidone (1-vinyl-2-pyrolidinone polymer, PVP)] with water in 3% (dry basis) concentration. Comparative data show that granules prepared with PVP have the best flow properties and minimum angle of repose, percentage fines, and compressibility, while granules of sodium carboxymethylcellulose could not be compressed into well-defined tablets. Tablets containing starch as a binder possess all the quality features. Tablets from acacia, however, give a poor dissolution profile. Ethyl cellulose has less effective granule formation, leading to poor quality tablets. Rank correlation with respect to solubility and absorption characteristics according to granulating agent in the formation is: starch greater than ethyl cellulose greater than PVP greater than acacia.
使用不同的黏合剂（淀粉、阿拉伯胶、乙基纤维素、羧甲基纤维素钠和聚维酮（1-乙烯基-2-吡咯烷酮聚合物，PVP））以3%（干基）的浓度与水混合制备了五批磺胺甲恶唑片。对比数据表明，用PVP制备的颗粒具有最佳的流动性，休止角、细粉百分比和可压性最小，而羧甲基纤维素钠颗粒无法压制成形状良好的片剂。含有淀粉作为黏合剂的片剂具备所有质量特性。然而，以阿拉伯胶为黏合剂的片剂溶出度较差。乙基纤维素的成粒效果较差，导致片剂质量不佳。根据制粒剂在制剂中关于溶解度和吸收特性的秩相关为：淀粉＞乙基纤维素＞PVP＞阿拉伯胶。
