Georgakopoulos P P, Malamataris S, Dolamidis G
Pharmazie. 1983 Apr;38(4):240-3.
The effects of using different grades of PVP and gelatin binders on three sieve fractions of lactose granulated in a fluidized bed granulator and tablets have been studied. Increasing the molecular mass of PVP or bloom number of gelatin resulted in a decrease in granule friability but in an increase in their average size and porosity and in the tensile strengths of the resulting tablets when compressed to a fixed apparent density. The results have been explained in terms of the effects of moist and dry binder bridges on bonding of particles in granules and tablets.
研究了使用不同等级的聚乙烯吡咯烷酮（PVP）和明胶粘合剂对在流化床制粒机中制粒的乳糖的三个筛分部分以及片剂的影响。提高PVP的分子量或明胶的勃氏粘度会导致颗粒脆性降低，但颗粒平均尺寸、孔隙率以及压制到固定表观密度时所得片剂的抗张强度增加。已根据湿粘合剂桥和干粘合剂桥对颗粒和片剂中颗粒结合的影响来解释这些结果。
