Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, Otto-Hahn-Straße 11, 44227 Dortmund, Germany.
Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, Otto-Hahn-Straße 11, 44227 Dortmund, Germany; Faculty of Chemistry and Chemical Biology, Technical University Dortmund, Otto-Hahn-Straße 6, 44221 Dortmund, Germany.
Curr Opin Chem Biol. 2020 Jun;56:111-118. doi: 10.1016/j.cbpa.2019.10.005. Epub 2020 May 1.
Through evolution, nature has provided natural products (NPs) as a rich source of diverse bioactive material. Many drug discovery programs have used nature as an inspiration for the design of NP-like compound classes. These concepts are guided by the prevalidated biological relevance of NPs while going beyond the limitations of nature to produce chemical matter that could have unexpected or novel bioactivities. Herein, we discuss, compare, and highlight recent examples of NP-inspired methods with a focus on the pseudo-NP concept.
通过进化，大自然为我们提供了天然产物（NPs），作为各种生物活性物质的丰富来源。许多药物发现计划都将大自然作为设计 NP 类似化合物类别的灵感来源。这些概念以 NPs 的生物学相关性为指导，同时超越自然的限制，产生可能具有意外或新颖生物活性的化学物质。本文讨论、比较和强调了最近受 NP 启发的方法的例子，重点是伪 NP 概念。
