Lee Chuen Wai, Blanco Borja, Dempsey Laura, Chalia Maria, Hebden Jeremy C, Caballero-Gaudes César, Austin Topun, Cooper Robert J
neoLAB, The Evelyn Perinatal Imaging Centre, The Rosie Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
Neonatal Intensive Care Unit, The Rosie Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
Front Neurosci. 2020 Apr 17;14:347. doi: 10.3389/fnins.2020.00347. eCollection 2020.
The spontaneous cerebral activity that gives rise to resting-state networks (RSNs) has been extensively studied in infants in recent years. However, the influence of sleep state on the presence of observable RSNs has yet to be formally investigated in the infant population, despite evidence that sleep modulates resting-state functional connectivity in adults. This effect could be extremely important, as most infant neuroimaging studies rely on the neonate to remain asleep throughout data acquisition. In this study, we combine functional near-infrared spectroscopy with electroencephalography to simultaneously monitor sleep state and investigate RSNs in a cohort of healthy term born neonates. During active sleep (AS) and quiet sleep (QS) our newborn neonates show functional connectivity patterns spatially consistent with previously reported RSN structures. Our three independent functional connectivity analyses revealed stronger interhemispheric connectivity during AS than during QS. In turn, within hemisphere short-range functional connectivity seems to be enhanced during QS. These findings underline the importance of sleep state monitoring in the investigation of RSNs.
近年来，引发静息态网络（RSNs）的自发性大脑活动在婴儿中得到了广泛研究。然而，尽管有证据表明睡眠会调节成年人的静息态功能连接，但睡眠状态对婴儿群体中可观察到的RSNs存在的影响尚未得到正式研究。这种影响可能极其重要，因为大多数婴儿神经影像学研究都依赖新生儿在整个数据采集过程中保持睡眠状态。在本研究中，我们将功能近红外光谱与脑电图相结合，以同时监测睡眠状态，并研究一组足月健康新生儿的RSNs。在主动睡眠（AS）和安静睡眠（QS）期间，我们的新生儿表现出与先前报道的RSN结构在空间上一致的功能连接模式。我们的三项独立功能连接分析显示，AS期间的半球间连接比QS期间更强。反过来，半球内短程功能连接在QS期间似乎增强。这些发现强调了睡眠状态监测在RSNs研究中的重要性。
