α-氟代β-氨基膦酸酯二肽类似物的高效合成
Efficient synthesis of dipeptide analogues of α-fluorinated β-aminophosphonates.
作者信息
Kaźmierczak Marcin, Koroniak Henryk
机构信息
Faculty of Chemistry, Adam Mickiewicz University in Poznań, Uniwersytetu Poznańskiego 8, 61-614 Poznań, Poland.
Centre for Advanced Technologies, Adam Mickiewicz University in Poznań, Uniwersytetu Poznańskiego 10, 61-614 Poznań, Poland.
出版信息
Beilstein J Org Chem. 2020 Apr 16;16:756-762. doi: 10.3762/bjoc.16.69. eCollection 2020.
Herein, we present an efficient synthesis of dipeptide analogues of α-fluorinated β-aminophosphonates. Each step of the synthesis was optimized to provide excellent yields. Moreover, the absolute configuration of the obtained compounds was determined by X-ray analysis, which proved the stereochemistry that was proposed based on NMR studies.
在此，我们展示了一种高效合成α-氟化β-氨基膦酸二肽类似物的方法。合成的每一步都经过优化以获得优异的产率。此外，通过X射线分析确定了所得化合物的绝对构型，这证实了基于核磁共振研究提出的立体化学结构。
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