在温和的反应条件下合成和表征一系列新型双（烯丙基-α-氨基膦酸酯）。
Synthesis and Characterization of a New Series of Bis(allylic-α-aminophosphonates) under Mild Reaction Conditions.
机构信息
Laboratory of Selective Organic & Heterocyclic Synthesis Biological Activity Evaluation (LR17ES01), Department of Chemistry, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis 2092, Tunisia.
Department of Organic Chemistry I, Faculty of Pharmacy and Lascaray Research Center, University of the Basque Country (UPV/EHU), Paseo de la Universidad 7, 01006 Vitoria, Spain.
出版信息
Molecules. 2023 Jun 9;28(12):4678. doi: 10.3390/molecules28124678.
Several bis(α-aminophosphonates) have been conveniently prepared in good yields using a straightforward multicomponent Kabachnik-Fields reaction between ethane 1,2-diamine or propane 1,3-diamine, diethylphosphite and aldehydes under catalyst-free conditions. The nucleophilic substitution reaction of bis(α-aminophosphonates) prepared and ethyl (2-bromomethyl)acrylate under mild reaction conditions afforded an original synthetic approach to a new series of bis(allylic-α-aminophosphonates).
几种双（α-氨基膦酸酯）已通过乙二胺或丙二胺、亚磷酸二乙酯和醛之间的直截了当的多组分 Kabachnik-Fields 反应，在无催化剂条件下以良好的产率方便地制备。温和反应条件下制备的双（α-氨基膦酸酯）与溴代丙烯酸乙酯的亲核取代反应提供了一种新颖的合成方法，用于制备一系列新的双（烯丙基-α-氨基膦酸酯）。
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