神经管缺陷的流行病学及决定因素：叙述性综述
Epidemiology and determinant factors of neural tube defect: Narrative review.
作者信息
Endalifer Melese Linger, Diress Gedefaw
机构信息
Departments of Midwifery, Woldia University, Woldia, Amhara, Ethiopia.
Public Health, Woldia University, Woldia, Amhara, Ethiopia.
出版信息
Surg Neurol Int. 2020 Apr 25;11:81. doi: 10.25259/SNI_84_2020. eCollection 2020.
BACKGROUND
The epidemiology of neural tube defect (NTD) is face ignorance from the global community. However, the problem is complex and it is a cause for child mortality and morbidity. We provide the latest insights with respect to determinant factors of NTD.
METHODS
Google Scholar and PubMed were systematically searched to identify potential research articles concerning the epidemiology and its determinant factors of NTD.
RESULTS
The epidemiology of Neural tube defects increased in some countries. The epidemiology and determinant factors were varies across countries,geographical regions and socioeconomic status of the populations. In general, the determinant factors of NTD were summarized as behavioral, nutrition-related, environmental, medical illness, and health service-related factors.
CONCLUSION
Birth defect is fatal which affects the new generation; specifically, NTD is the problem of middle and low-income countries. It is a direct cause for neonatal and perinatal mortality rate globally. Even if little factors identified, yet conducting experimental and clinical trial researches are a better approach to slow down the progress.
背景
神经管缺陷（NTD）的流行病学情况在全球范围内仍鲜为人知。然而，这个问题很复杂，它是儿童死亡和发病的一个原因。我们提供了关于神经管缺陷决定因素的最新见解。
方法
系统检索谷歌学术和PubMed，以确定有关神经管缺陷流行病学及其决定因素的潜在研究文章。
结果
神经管缺陷的流行病学情况在一些国家有所增加。其流行病学情况和决定因素因国家、地理区域以及人群的社会经济状况而异。一般来说，神经管缺陷的决定因素可归纳为行为、营养相关、环境、疾病以及卫生服务相关因素。
结论
出生缺陷是致命的，会影响新一代；具体而言，神经管缺陷是中低收入国家面临的问题。它是全球新生儿和围产期死亡率的直接原因。即使已确定的因素很少，但进行实验和临床试验研究仍是减缓这一进程的更好方法。
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