Muranaka Yosuke, Matsubara Kenta, Maki Taisuke, Asano Shusaku, Nakagawa Hiroyuki, Mae Kazuhiro
Department of Chemical Engineering, Kyoto University, Kyoto 615-8510, Japan.
Institute for Materials Chemistry and Engineering, Kyushu University, Fukuoka 816-8580, Japan.
ACS Omega. 2020 Apr 15;5(16):9384-9390. doi: 10.1021/acsomega.0c00399. eCollection 2020 Apr 28.
5-Hydroxymethylfurfural (HMF) was synthesized from monosaccharides by a biphasic reaction system using a microreactor. The biphasic reaction system realized an immediate extraction and stabilization of product HMF, which further degrades under the reaction conditions. Segmented flow was utilized for an efficient reaction-extraction tool. The effect of extraction ability was evaluated based on the extraction phase/reaction phase partition coefficient of HMF. A Lewis acid catalyst was introduced to overcome the obstacle of the reaction, which was clarified as the isomerization of glucose to fructose, and improved the HMF yield to 85 mol % under the condition of = 180 °C and τ = 47 min. The recovery of the product HMF was also examined using a constructed microextraction system, and HMF was selectively recovered from the extraction phase.
采用微反应器，通过双相反应体系由单糖合成了5-羟甲基糠醛（HMF）。该双相反应体系实现了产物HMF的即时萃取和稳定化，否则HMF在反应条件下会进一步降解。采用分段流作为高效的反应-萃取工具。基于HMF的萃取相/反应相分配系数评估萃取能力的影响。引入路易斯酸催化剂以克服反应障碍，该障碍被明确为葡萄糖异构化为果糖，并在180°C和τ = 47分钟的条件下将HMF产率提高到85 mol%。还使用构建的微萃取系统研究了产物HMF的回收情况，并且从萃取相中选择性地回收了HMF。
