Román-Leshkov Yuriy, Chheda Juben N, Dumesic James A
Department of Chemical and Biological Engineering, University of Wisconsin, Madison, WI 53706, USA.
Science. 2006 Jun 30;312(5782):1933-7. doi: 10.1126/science.1126337.
Furan derivatives obtained from renewable biomass resources have the potential to serve as substitutes for the petroleum-based building blocks that are currently used in the production of plastics and fine chemicals. We developed a process for the selective dehydration of fructose to 5-hydroxymethylfurfural (HMF) that operates at high fructose concentrations (10 to 50 weight %), achieves high yields (80% HMF selectivity at 90% fructose conversion), and delivers HMF in a separation-friendly solvent. In a two-phase reactor system, fructose is dehydrated in the aqueous phase with the use of an acid catalyst (hydrochloric acid or an acidic ion-exchange resin) with dimethylsulfoxide and/or poly(1-vinyl-2-pyrrolidinone) added to suppress undesired side reactions. The HMF product is continuously extracted into an organic phase (methylisobutylketone) modified with 2-butanol to enhance partitioning from the reactive aqueous solution.
从可再生生物质资源中获得的呋喃衍生物有潜力替代目前用于塑料和精细化学品生产的石油基原料。我们开发了一种将果糖选择性脱水制备5-羟甲基糠醛（HMF）的工艺，该工艺在高果糖浓度（10至50重量%）下运行，实现了高收率（果糖转化率为90%时HMF选择性达80%），并在一种便于分离的溶剂中得到HMF。在两相反应器系统中，果糖在水相中使用酸催化剂（盐酸或酸性离子交换树脂）进行脱水，并添加二甲基亚砜和/或聚（1-乙烯基-2-吡咯烷酮）以抑制不期望的副反应。HMF产物被连续萃取到用2-丁醇改性的有机相（甲基异丁基酮）中，以增强从反应性水溶液中的分配。
