Mariano Marcos, Bernardinelli Oigres Daniel, Pires-Oliveira Rafael, Ferreira Guilherme A, Loh Watson
Institute of Chemistry, University of Campinas (UNICAMP), CP 6154, CEP 13083-970 Campinas, São Paulo, Brazil.
ACS Omega. 2020 Apr 17;5(16):9517-9528. doi: 10.1021/acsomega.0c00741. eCollection 2020 Apr 28.
The preparation of inclusion complexes based on α-cyclodextrin (α-CD) and oligo(ethylene glycol) methyl ether methacrylate (OEGMA) was investigated aiming to reveal complexation particularities and thermodynamic and kinetic aspects as a function of the oligomer architecture. Small-angle X-ray scattering and isothermal titration calorimetry measurements revealed that oligomer molecular weight controls both the kinetics and thermodynamics of inclusion. Unlike linear ethylene glycol polymers, OEGMA groups possess a methacrylate group, which seems to act as a stopper, affecting their mode of complexation. Nuclear magnetic resonance spectra and relaxation measurements support the fact that methacrylate groups lie outside the α-CD ring and that a full sequential complexation of the oligomer ethylene oxide groups is not observed. These results allied to the temperature sensitivity of these oligomers and enable possible routes for chemical modifications and design of new stimuli-responsive materials.
研究了基于α-环糊精（α-CD）和聚乙二醇甲基丙烯酸甲酯（OEGMA）的包合物的制备，旨在揭示作为低聚物结构函数的络合特性以及热力学和动力学方面。小角X射线散射和等温滴定量热法测量表明，低聚物分子量控制着包合的动力学和热力学。与线性乙二醇聚合物不同，OEGMA基团具有甲基丙烯酸酯基团，该基团似乎起到了封端剂的作用，影响其络合模式。核磁共振光谱和弛豫测量支持以下事实：甲基丙烯酸酯基团位于α-CD环之外，并且未观察到低聚物环氧乙烷基团的完全顺序络合。这些结果与这些低聚物的温度敏感性相关，并为化学修饰和新型刺激响应材料的设计提供了可能的途径。
