Department of Applied Chemistry, Kyushu University , Fukuoka 819-0395, Japan.
Department of Automotive Science, Kyushu University , Fukuoka 819-0395, Japan.
Langmuir. 2018 Jan 16;34(2):709-714. doi: 10.1021/acs.langmuir.7b03130. Epub 2017 Oct 12.
The polymer dynamics at the water interface play a crucial role in the manifestation of biorelated functions. One of the strategies for this is to form inclusion complexes of polymer chains with cyclic compounds. However, such an idea has been limited to bulk materials so far. Here we propose a preparation pathway for a polyrotaxane structure composed of poly(ethylene oxide) (PEO) and α-cyclodextrin (CD) at the outermost surface of a glassy poly(methyl methacrylate) film on the basis of the combination of a click reaction and the Langmuir-Blodgett method. The chain motion of PEO at the water interface could be regulated by threading of CD molecules on PEO and thereby the biological responses such as protein adsorption and platelet adhesion altered depending on the extent of complexation.
聚合物在水界面上的动力学行为在表现生物相关功能方面起着至关重要的作用。实现这一目标的策略之一是形成聚合物链与环状化合物的包络复合物。然而，到目前为止，这种想法仅限于体材料。在这里，我们基于点击反应和 Langmuir-Blodgett 方法的结合，提出了在玻璃态聚甲基丙烯酸甲酯薄膜的最外层表面上制备由聚（氧化乙烯）（PEO）和α-环糊精（CD）组成的聚轮烷结构的方法。通过 CD 分子在 PEO 上的穿线，可以调节 PEO 在水界面上的链运动，从而改变蛋白质吸附和血小板黏附等生物响应，具体取决于复合物的程度。
