UCL Eastman Dental Institute, London, UK.
Department of Oral Medicine, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
Oral Dis. 2020 Oct;26(7):1464-1473. doi: 10.1111/odi.13379. Epub 2020 May 26.
To evaluate the responsiveness of measures of pain and oral health-related quality of life (OH-QoL) in patients with oral lichen planus (OLP) and to determine thresholds for minimal important change (MIC) and minimal important difference (MID) for use in this patient population.
Data from baseline and 4-month follow-up including Visual Analog Scale (VAS), Numerical Rating Scale (NRS), 14-item Oral Health Impact Profile (OHIP-14), 15-item and 26-item Chronic Oral Mucosal Disease Questionnaire (COMDQ-15; COMDQ-26) were collected from 157 patients with OLP. Responsiveness was assessed by testing hypotheses and calculating the area under the curve. MIC and MID were established based on triangulation of distribution-based and anchor-based estimates.
The results supported adequate responsiveness of VAS, NRS, COMDQ-15 and COMDQ-26 for use in OLP, while the OHIP-14 demonstrated relatively low sensitivity to detect improvement in the OLP status. Recommended meaningful improvement thresholds were as follows: VAS (MIC 16 mm; MID 18 mm), NRS (MIC/MID 2 points), OHIP-14 (MIC/MID 5 points), COMDQ-15 (MIC 5 points; MID 6 points) and COMDQ-26 (MIC/MID 9 points).
This study provides some evidence of responsiveness as well as establishing meaningful improvement thresholds in scores of pain and OH-QoL measures in OLP.
评估口腔扁平苔藓（OLP）患者疼痛和口腔健康相关生活质量（OH-QoL）测量的反应能力，并确定在该患者群体中使用的最小重要变化（MIC）和最小重要差异（MID）阈值。
从基线和 4 个月随访中收集了 157 例 OLP 患者的视觉模拟量表（VAS）、数字评定量表（NRS）、14 项口腔健康影响量表（OHIP-14）、15 项和 26 项慢性口腔黏膜疾病问卷（COMDQ-15；COMDQ-26）数据。通过检验假设和计算曲线下面积来评估反应能力。基于分布和基于锚的估计的三角剖分确定 MIC 和 MID。
结果支持 VAS、NRS、COMDQ-15 和 COMDQ-26 在 OLP 中具有足够的反应能力，而 OHIP-14 对检测 OLP 状况的改善则相对不敏感。推荐的有意义的改善阈值如下：VAS（MIC 16mm；MID 18mm）、NRS（MIC/MID 2 分）、OHIP-14（MIC/MID 5 分）、COMDQ-15（MIC 5 分；MID 6 分）和 COMDQ-26（MIC/MID 9 分）。
本研究为疼痛和 OH-QoL 测量的反应能力提供了一些证据，并确定了 OLP 中得分的有意义的改善阈值。
