Wang Yinmin, Ma Jie, Zhang Zhaofeng, Shen Hua
Department of Plastic Surgery, Shanghai First People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Dermatol Ther. 2020 Jul;33(4):e13494. doi: 10.1111/dth.13494. Epub 2020 May 19.
Keloids are firm, fibrous nodules that form on an individual's skin and are associated with difficult symptoms as well as high recurrence rates. This study aims to improve the surgical techniques that reduce local tension after surgical excision of keloids as well as applying adjuvant radiotherapy to suppress scar formation. A total of 58 patients aged between 21 and 76 years received surgical incision of keloid and immediate postoperation low-dose radiotherapy. All patient follow-ups were performed at the out-patient department. Any sign of a keloid at the incision site was defined as treatment failure or keloid recurrence, regardless of the size. At a median follow-up of 22 months, the overall recurrence for all lesions was 8.6%, which is improved compared with previous study. In addition, all incisions performed during surgeries were healed and no signs of necrosis or the development of ulcers was observed. Our study suggests that this combined therapy provides excellent local control of keloids and shows promise for future therapy.
瘢痕疙瘩是在个体皮肤上形成的坚硬纤维性结节，伴有棘手的症状以及高复发率。本研究旨在改进手术技术，以减少瘢痕疙瘩手术切除后的局部张力，并应用辅助放疗来抑制瘢痕形成。共有58例年龄在21至76岁之间的患者接受了瘢痕疙瘩手术切除及术后即刻低剂量放疗。所有患者均在门诊进行随访。切口部位出现任何瘢痕疙瘩迹象均被定义为治疗失败或瘢痕疙瘩复发，无论其大小。中位随访22个月时，所有病变的总体复发率为8.6%，与先前研究相比有所改善。此外，手术期间进行的所有切口均愈合，未观察到坏死或溃疡形成的迹象。我们的研究表明，这种联合治疗对瘢痕疙瘩具有出色的局部控制效果，并为未来治疗带来了希望。
