Bischof Marc, Krempien Robert, Debus Juergen, Treiber Martina
Department of Radiooncology, University of Heidelberg, Heidelberg, Germany.
Int J Dermatol. 2007 Sep;46(9):971-5. doi: 10.1111/j.1365-4632.2007.03326.x.
To evaluate the role of postoperative radiotherapy in the management of keloids.
Forty-seven patients with a combined total of 60 keloids were treated with 6-MeV electron beam radiotherapy after surgical excision of the keloids. Mean daily fractions of 4 Gy (range, 3-5 Gy) were administered up to a total dose of 16 Gy (range, 12-18 Gy). The median follow-up was 70 months. Patients were asked to complete a questionnaire addressing their satisfaction with the treatment results. This self-assessment was compared with the clinical outcome.
Four keloids (7%) relapsed completely, and five recurrences (8%) were classified as limited relapses. All recurrences were observed at sites of high stretch-tension. Keloid-associated symptoms, e.g. itching and pain, were improved in 81%. Hypopigmentation was observed in 29 patients (62%), a mild redness of the scar in eight patients (17%), and grade 1 telangiectasias in two patients (4%). No severe complications or secondary malignancies were observed. Self-assessments did not fully correspond to the clinical examination and recurrence status. Twelve patients were not satisfied with the treatment result, but only two of these relapsed completely. Three relapsed patients described the result of therapy as excellent or good.
Postoperative electron radiotherapy is well tolerated and very effective in preventing keloid recurrence. To avoid an overestimation of cosmetic outcome, patients should be informed about achievable results before therapy starts.
评估术后放疗在瘢痕疙瘩治疗中的作用。
47例患者共60个瘢痕疙瘩,在手术切除瘢痕疙瘩后接受6兆电子伏电子束放疗。平均每日分次给予4戈瑞(范围3 - 5戈瑞),总剂量达16戈瑞(范围12 - 18戈瑞)。中位随访时间为70个月。要求患者完成一份关于对治疗结果满意度的问卷。将这种自我评估与临床结果进行比较。
4个瘢痕疙瘩(7%)完全复发,5个复发(8%)被归类为局限性复发。所有复发均出现在高拉伸张力部位。81%的患者瘢痕疙瘩相关症状如瘙痒和疼痛得到改善。29例患者(62%)出现色素减退,8例患者(17%)瘢痕轻度发红,2例患者(4%)出现1级毛细血管扩张。未观察到严重并发症或继发性恶性肿瘤。自我评估与临床检查及复发情况不完全相符。12例患者对治疗结果不满意,但其中只有2例完全复发。3例复发患者将治疗结果描述为优秀或良好。
术后电子放疗耐受性良好,在预防瘢痕疙瘩复发方面非常有效。为避免对美容效果估计过高,应在治疗开始前告知患者可达到的效果。