Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, 1400 Pressler St, Houston, TX 77030, USA.
Department of General Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.
Biotechniques. 2020 Jul;69(1):395-403. doi: 10.2144/btn-2020-0021. Epub 2020 May 2.
Methods for imaging orthotopic prostate tumors within the prostate or small tumors with extension outside the prostate are needed to more closely model human prostate tumors, which are most commonly located within the gland or may extend just through the gland. By comparing MR sequences, we found that the T2-based Dixon 'water only' sequence best visualized tumors within the prostate of mouse models in both young and old mice and that tumor weight derived from this sequence correlated highly with tumor weight (r = 0.98, p < 0.001, n = 12). This should aid tumor detection, margin delineation and evaluation of tumor burden to enable studies including, but not limited to, evaluating the natural history of the disease, the mechanisms of action and the efficacy of therapeutic interventions.
需要能够在前列腺内或前列腺外延伸的小肿瘤中对原位前列腺肿瘤进行成像的方法，以便更接近地模拟人前列腺肿瘤，这些肿瘤最常见于腺体内部或仅延伸穿过腺体。通过比较磁共振序列，我们发现基于 T2 的 Dixon“仅水”序列在年轻和老年小鼠模型中最能可视化前列腺内的肿瘤，并且该序列得出的肿瘤重量与肿瘤重量高度相关（r=0.98，p<0.001，n=12）。这将有助于肿瘤检测、边缘描绘和肿瘤负担评估，以进行包括但不限于评估疾病自然史、作用机制和治疗干预效果的研究。
