超声动态评估急性百草枯中毒患者的肺损伤。
Dynamic assessment of lung injury by ultrasound in patients with acute paraquat poisoning.
机构信息
Department of Intensive Care Unit, The First Hospital of Jiaxing, Jiaxing, China.
Department of Intensive Care Unit, The First Affiliated Hospital of Jiaxing University, Jiaxing, China.
出版信息
J Int Med Res. 2020 May;48(5):300060520920435. doi: 10.1177/0300060520920435.
OBJECTIVE
To investigate the value of ultrasound in the dynamic assessment of lung injury after acute paraquat poisoning.
METHODS
A prospective observational study was performed on patients with paraquat poisoning from admission to day 28 or discharge. Ultrasound assessment of the lungs was performtyed every 48 hours. The correlation of the lung ultrasound score (LUS) with other indicators was analyzed.
RESULTS
Twenty-six patients were enrolled, with an average age of 46 ± 16 years. The average toxic dose was 95 ± 51 mL. The intensive care unit (ICU) stay averaged 9 ± 8 days, and the 28-day mortality was 88.5%. There was a significant negative correlation between LUS and oxygenation index (rho = -0.896) and a significant positive correlation between LUS and carbon dioxide concentration (rho = 0.567). Lung ultrasound and computed tomography imaging correlated closely.
CONCLUSION
Lung ultrasound can reflect changes in lung status in patients with paraquat poisoning and can be used to evaluate lung injury in these patients. ChiCTR, ChiCTR-DDD-16010211. Registered 21 December 2016, http://www.chictr.org.cn/listbycreater.aspx .
目的
探讨超声在急性百草枯中毒后肺损伤动态评估中的价值。
方法
前瞻性观察性研究纳入从入院到第 28 天或出院的百草枯中毒患者。每 48 小时进行一次肺部超声评估。分析肺超声评分（LUS）与其他指标的相关性。
结果
共纳入 26 例患者，平均年龄 46±16 岁。平均中毒剂量为 95±51 mL。重症监护病房（ICU）入住时间平均为 9±8 天，28 天死亡率为 88.5%。LUS 与氧合指数呈显著负相关（rho=-0.896），与二氧化碳浓度呈显著正相关（rho=0.567）。肺超声与计算机断层扫描成像密切相关。
结论
肺超声可反映百草枯中毒患者肺部状况的变化，可用于评估此类患者的肺损伤。ChiCTR，ChiCTR-DDD-16010211。注册于 2016 年 12 月 21 日，http://www.chictr.org.cn/listbycreater.aspx。
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