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黏膜类天疱疮伴 COVID-19 经大剂量静脉注射免疫球蛋白治疗:病例报告。

Mucous membrane pemphigoid and COVID-19 treated with high-dose intravenous immunoglobulins: a case report.

机构信息

Department of Dermatology, Autoimmune Bullous Diseases Research Center, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Department of Infectious Diseases, Autoimmune Bullous Diseases Research Center, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

J Dermatolog Treat. 2020 Aug;31(5):446-447. doi: 10.1080/09546634.2020.1764472. Epub 2020 May 15.

Abstract

This is a report of a case with mucous membrane pemphigoid (MMP) with severe eye involvement and concurrent COVID-19 treated successfully using simultaneous high dose intravenous immunoglobulin (IVIg) and anti-viral treatment as hydroxychloroquine, lopinavir/ritonavir, and ribavirin. He had finished a 2-g cycle of rituximab (RTX) in late January. He was receiving mycophenolate mofetil (MMF) for one month and 30 mg prednisolone for three months until his hospitalization. Prednisolone was tapered to 15 mg when current COVID-19 was suspected, considering his recent cough, dyspnea, and fever.

摘要

这是一例黏膜类天疱疮(MMP)伴严重眼部受累和合并 COVID-19 的病例,采用同时给予大剂量静脉注射免疫球蛋白(IVIg)和抗病毒治疗(如羟氯喹、洛匹那韦/利托那韦和利巴韦林)成功治疗。他于 1 月底完成了利妥昔单抗(RTX)的 2 克疗程。他在住院前接受霉酚酸酯(MMF)治疗一个月,泼尼松龙治疗三个月,剂量为 30mg。由于他近期有咳嗽、呼吸困难和发热,当怀疑为 COVID-19 时,将泼尼松龙逐渐减至 15mg。

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