Department of Pharmacology, School of Basic Medical Sciences, Hebei University of Chinese Medicine, Shijiazhuang 050200, Hebei Province, China.
College of Basic Medicine, Hebei Medical University, Shijiazhuang 050017, Hebei Province, China.
Curr Drug Targets. 2020;21(11):1099-1104. doi: 10.2174/1389450121666200504080112.
Among the major components of green tea, epigallocatechin-3-gallate (EGCG) is the most effective for its anti-cancer characteristics. The bulk of studies provide the mechanisms of suppressive function of EGCG are involved in alteration of cancer cell cycle, development, and apoptosis through activation/inhibition of several signal pathways. Another mechanism that explains the multiple effects exerted by EGCG in cancer is the epigenetic change by DNA methylation or methyltransferases, histone acetylation or deacetylases, and no coding RNAs (micoRNAs). Furthermore, decontrolled expression of miRNA transcription has been tested to be directly regulated by oncogenic and tumor-suppressor transcription factors. Recently, several proteins have been identified as miRNA direct interactors by EGCG. However, the mechanisms explaining the action of miRNA being modulated by EGCG have not been completely understood yet. This review summarizes the state of epigenetic change being modulated by EGCG in a variety of cancers and oncogenic and tumor-suppressor transcription factors.
在绿茶的主要成分中，表没食子儿茶素没食子酸酯（EGCG）因其抗癌特性最为有效。大量研究提供的机制表明，EGCG 通过激活/抑制几种信号通路来改变癌细胞周期、发育和凋亡，从而发挥抑制功能。另一种机制解释了 EGCG 在癌症中发挥的多种作用，即通过 DNA 甲基化或甲基转移酶、组蛋白乙酰化或去乙酰化以及非编码 RNA（miRNAs）进行表观遗传改变。此外，已测试出 miRNA 转录的失控表达可直接受致癌和肿瘤抑制转录因子调控。最近，已经鉴定出几种蛋白质是 EGCG 的 miRNA 直接相互作用蛋白。然而，miRNA 被 EGCG 调节的作用机制尚未完全阐明。这篇综述总结了 EGCG 在多种癌症和致癌及肿瘤抑制转录因子中调节表观遗传改变的状态。
