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多发伤患者焦虑和抑郁的患病率、损伤相关因素和非损伤相关因素-一项回顾性 20 年随访研究。

Prevalence, injury-, and non-injury-related factors associated with anxiety and depression in polytrauma patients - A retrospective 20 year follow-up study.

机构信息

Department of Trauma, UniversitätsSpital Zürich, Zürich, Switzerland.

Harald Tscherne Laboratory, Department of Trauma, University Zurich, University Hospital Zurich, Zurich, Switzerland.

出版信息

PLoS One. 2020 May 4;15(5):e0232678. doi: 10.1371/journal.pone.0232678. eCollection 2020.

Abstract

INTRODUCTION

Survival rate after polytrauma increased over the past decades resulting in an increase of long-term complaints. These include physical and psychological impairments. The aim of this study was to describe the prevalence and risk factors for developing depression and anxiety more than twenty years after polytrauma.

METHODS

We contacted patients who were treated due to a polytrauma between 1973 and 1990 at one level 1 trauma center after more than 20 years. These patients received a self-administered questionnaire, to assess symptoms of depression and anxiety. Analysis based on multivariable logistic regression models include injury severity and non-injury related factors to determine risk factors associated with the development of depression and anxiety.

RESULTS

Patients included in this study (n = 337) had a mean ISS of 20.3 (4 to 50) points. In total, 173 (51.3%) showed psychiatric sequelae (depression n = 163, 48.2%; anxiety n = 14, 4.1%). Injury severity was not associated with the development of depression or anxiety. However, the patients, who required psychiatric therapy prior to the injury had higher risk of developing psychiatric symptoms (OR 1.3, 95%CI 1.1 to 1.8, p = 0.018) as did patients who suffered from additional psychiatric insults after the injury (OR 1.4, 95%CI 1.2 to 2.0, p = 0.049).

CONCLUSION

More than half of polytrauma patients developed psychiatric sequelae. Risk factors include mainly non-injury related factors such as psychiatric comorbidities and additional psychiatric insults after the injury.

摘要

简介

过去几十年来,多发伤患者的生存率有所提高,导致长期并发症的发生率也有所增加。这些并发症包括身体和心理方面的损伤。本研究旨在描述多发伤二十多年后出现抑郁和焦虑的患病率和危险因素。

方法

我们联系了在 1973 年至 1990 年期间在一家一级创伤中心接受治疗的多发伤患者,这些患者在 20 多年后接受了自我管理的问卷调查,以评估抑郁和焦虑症状。基于多变量逻辑回归模型的分析包括损伤严重程度和非损伤相关因素,以确定与抑郁和焦虑发展相关的危险因素。

结果

本研究纳入的患者(n=337)平均 ISS 为 20.3(4 至 50)分。共有 173 例(51.3%)出现精神后遗症(抑郁 163 例,48.2%;焦虑 14 例,4.1%)。损伤严重程度与抑郁或焦虑的发生无关。然而,在受伤前需要精神治疗的患者发生精神症状的风险更高(OR 1.3,95%CI 1.1 至 1.8,p=0.018),受伤后发生额外精神创伤的患者也如此(OR 1.4,95%CI 1.2 至 2.0,p=0.049)。

结论

超过一半的多发伤患者出现了精神后遗症。危险因素主要是非损伤相关因素,如精神共病和受伤后的额外精神创伤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc85/7197792/7f5887abc62e/pone.0232678.g001.jpg

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