通过 1,2-二氢吡啶与 Selectfluor 的亲电氟化反应合成氟化 3,6-二氢吡啶和 2-(氟甲基)吡啶。
Synthesis of Fluorinated 3,6-Dihydropyridines and 2-(Fluoromethyl)pyridines by Electrophilic Fluorination of 1,2-Dihydropyridines with Selectfluor.
机构信息
Latvian Institute of Organic Synthesis, Aizkraukles Str. 21, LV-1006 Riga, Latvia.
Institute of Organic Chemistry NAS of Ukraine, Murmanska Str. 5, 02660 Kyiv, Ukraine.
出版信息
Molecules. 2020 Jul 9;25(14):3143. doi: 10.3390/molecules25143143.
New fluorinated 3,6-dihydropyridines were obtained by the electrophilic fluorination of 1,2-dihydropyridines with Selectfluor. These 3-fluoro-3,6-dihydropyridines were easily converted to corresponding pyridines by the elimination of hydrogen fluoride under mild conditions. A new approach to the synthesis of methyl 2-(fluoromethyl)-5-nitro-6-arylnicotinates by the fluorination of 3-fluoro-2-methyl-5-nitro-3,6-dihydropyridines or 1,2-dihydropyridines with Selectfluor has been developed.
新的氟化 3,6-二氢吡啶通过 1,2-二氢吡啶的 Selectfluor 亲电氟化得到。这些 3-氟-3,6-二氢吡啶在温和条件下通过消除氟化氢很容易转化为相应的吡啶。通过 Selectfluor 对 3-氟-2-甲基-5-硝基-3,6-二氢吡啶或 1,2-二氢吡啶进行氟化，开发了一种合成甲基 2-(氟甲基)-5-硝基-6-芳基烟酸酯的新方法。
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