Department of Pathology, Chungnam National University Hospital, Daejeon, Republic of Korea.
Department of Pathology, College of Medicine, Hanyang University, Seoul, Republic of Korea.
Anticancer Res. 2020 May;40(5):2961-2967. doi: 10.21873/anticanres.14275.
BACKGROUND/AIM: Microtubule-associated tumor suppressor 1 (MTUS1) is a novel tumor suppressor involved in proliferation and migration, and down-regulation of MTUS1 is associated with the poor prognosis of several cancers. We evaluated the clinicopathological significance of MTUS1 expression in renal cell carcinoma (RCC).
We assessed MTUS1 expression by immunohistochemical staining of tissue microarrays from 249 cases of RCC. We analyzed the correlation of MTUS1 expression and clinicopathological characteristics. Additionally, we used public databases and performed bioinformatics analysis.
We investigated The Cancer Genome Atlas databases and identified that MTUS1 mRNA expression was significantly lower in RCC tissues than in normal tissues. Loss of MTUS1 expression was correlated with high WHO/ISUP nuclear grade, lymphovascular invasion, renal vein thrombus, and high pT stage in patients with RCC. Although there was no statistically significant correlation between MTUS1 expression and patients' prognosis in our cohort, MTUS1 overexpression was significantly correlated with a favorable prognosis in public data.
Loss of MTUS1 expression in RCC might be a potential biomarker for predicting clinical outcome.
背景/目的：微管相关肿瘤抑制因子 1（MTUS1）是一种参与增殖和迁移的新型肿瘤抑制因子，MTUS1 的下调与几种癌症的预后不良有关。我们评估了 MTUS1 在肾细胞癌（RCC）中的表达的临床病理意义。
我们通过对 249 例 RCC 组织微阵列进行免疫组织化学染色来评估 MTUS1 的表达。我们分析了 MTUS1 表达与临床病理特征的相关性。此外，我们使用公共数据库并进行了生物信息学分析。
我们研究了癌症基因组图谱数据库，并发现 MTUS1 mRNA 在 RCC 组织中的表达明显低于正常组织。MTUS1 表达缺失与 RCC 患者的高 WHO/ISUP 核分级、血管淋巴管浸润、肾静脉血栓形成和高 pT 期相关。尽管在我们的队列中，MTUS1 表达与患者预后之间没有统计学显著相关性，但在公共数据中，MTUS1 过表达与预后良好显著相关。
RCC 中 MTUS1 表达缺失可能是预测临床结局的潜在生物标志物。
