Park Hosub, Jee Seungyun, Son Hwangkyu, Cha Hyebin, Bang Seongsik, Ahn Byung Kyu, Myung Jaekyung, Paik Seungsam, Kim Hyunsung
Department of Pathology, Hanyang University Hospital, Hanyang University College of Medicine, Seoul 04763, Republic of Korea.
Department of Surgery, Hanyang University Hospital, Hanyang University College of Medicine, Seoul 04763, Republic of Korea.
Diagnostics (Basel). 2023 Mar 16;13(6):1140. doi: 10.3390/diagnostics13061140.
Microtubule-associated tumor suppressor 1 (MTUS1) is a novel tumor suppressor protein involved in cell proliferation, migration, and tumor growth. MTUS1 is thought to be downregulated in various human cancers and associated with poor prognosis. We evaluated the clinicopathologic significance and prognostic value of MTUS1 in colorectal adenocarcinoma.
Immunohistochemical staining for MTUS1 was performed on tissue microarrays of 393 colorectal adenocarcinoma cases, and MTUS1 staining was classified into high- and low-expression groups. Then, we investigated the correlations between MTUS1 protein expression and various clinicopathological parameters and patient survival.
MTUS1 protein was expressed at various grade levels in the cytoplasm of tumor cells, which showed loss or decreased expression of MTUS1. A total of 253 cases (64.4%) were classified into the low MTUS1 protein expression group and 140 cases (35.6%) into the high MTUS1 expression group. A low level of MTUS1 protein significantly correlated with tumor size ( = 0.047), histological grade ( < 0.001), lymphovascular invasion ( < 0.001), perineural invasion ( = 0.047), and lymph node metastasis ( < 0.001). Survival analyses showed that patients with low MTUS1 protein expression had worse overall survival ( = 0.007, log-rank test) and worse recurrence-free survival ( = 0.019, log-rank test) than those with high MTUS1 expression.
Low MTUS1 protein expression is associated with adverse clinicopathological characteristics and poor survival outcomes in patients with colorectal adenocarcinoma. These results suggest that MTUS1 functions as a tumor suppressor in colorectal adenocarcinoma and could be a potential prognostic biomarker.
微管相关肿瘤抑制因子1（MTUS1）是一种新型肿瘤抑制蛋白，参与细胞增殖、迁移和肿瘤生长。MTUS1被认为在多种人类癌症中表达下调，并与预后不良相关。我们评估了MTUS1在结直肠癌中的临床病理意义和预后价值。
对393例结直肠癌病例的组织芯片进行MTUS1免疫组化染色，并将MTUS1染色分为高表达组和低表达组。然后，我们研究了MTUS1蛋白表达与各种临床病理参数及患者生存率之间的相关性。
MTUS1蛋白在肿瘤细胞胞质中呈不同程度表达，显示MTUS1表达缺失或降低。共有253例（64.4%）被归为MTUS1蛋白低表达组，140例（35.6%）归为MTUS1高表达组。MTUS1蛋白低水平与肿瘤大小（P = 0.047）、组织学分级（P < 0.001）、淋巴管浸润（P < 0.001）、神经周围浸润（P = 0.047）和淋巴结转移（P < 0.001）显著相关。生存分析显示，MTUS1蛋白低表达患者的总生存期（P = 0.007，对数秩检验）和无复发生存期（P = 0.019，对数秩检验）均比MTUS1高表达患者差。
MTUS1蛋白低表达与结直肠癌患者不良的临床病理特征和较差的生存结果相关。这些结果表明MTUSI在结直肠癌中起肿瘤抑制作用，可能是一种潜在的预后生物标志物。
