Department of Endocrinology, Carol Davila University of Medicine and Pharmacy, 34-38 Aviatorilor Blvd., 011863, Bucharest, Romania.
Department of Pituitary and Neuroendocrine Disorders, C. I. Parhon National Institute of Endocrinology, 34-38 Aviatorilor Blvd., 011863, Bucharest, Romania.
Arch Osteoporos. 2020 May 4;15(1):66. doi: 10.1007/s11657-020-00744-1.
We measured serum parathyroid hormone in 8409 Romanian subjects and found a mild seasonal variation with highest levels in March and lowest levels in September. PTH was dependent on serum vitamin D, particularly below 12.82 ng/mL. Together, these suggest that vitamin D supplementation is warranted only in at-risk groups.
Seasonal variation of parathyroid hormone (PTH) and its dependency on serum 25-hydroxy vitamin D (25(OH)D) levels are well-described. However, there are few studies from Europe, and genetic, nutritional, and cultural differences are important. We describe the seasonal variation of serum PTH and its relation with serum 25(OH)D levels in Romania.
We retrieved from our endocrinology center database all PTH measurements between 2011 and 2019 together with age, sex, diagnosis, and date of blood sampling. Simultaneous serum 25(OH)D levels were partially available. Intact PTH was measured using the same electrochemiluminescence assay.
There were 8409 subjects (median age 49 (36, 60) years; 20.5% men) without a diagnosis of hyperparathyroidism (primary or secondary to chronic kidney disease), hypoparathyroidism, or low bone mass. Serum PTH showed a mild seasonal variation with highest levels at the end of March (47.61 pg/mL) and lowest levels at the end of September (43.15 pg/mL). All sex and age subgroups showed highest levels in the spring and lowest levels in the fall. Males had significantly lower PTH levels than females irrespective of season. PTH correlated inversely with serum 25(OH)D with a breakpoint of 12.82 ng/mL in 2800 subjects who had a simultaneous measurement of 25(OH)D. Increasing age was associated with increasing PTH levels independently of serum 25(OH)D.
We showed a mild seasonal variation of serum PTH in Romania, at an inverse sinusoidal pattern than serum 25(OH)D. The breakpoint on the PTH-25(OH)D correlation suggests that vitamin D supplementation is warranted only in at-risk groups.
甲状旁腺激素 (PTH) 的季节性变化及其对血清 25-羟维生素 D (25[OH]D) 水平的依赖性已有详细描述。然而，来自欧洲的研究较少，遗传、营养和文化差异很重要。我们描述了罗马尼亚血清 PTH 的季节性变化及其与血清 25(OH)D 水平的关系。
我们从内分泌中心的数据库中检索了 2011 年至 2019 年期间所有的 PTH 测量值，以及年龄、性别、诊断和采血日期。部分同时测量了血清 25(OH)D 水平。使用相同的电化学发光测定法测量完整的 PTH。
共有 8409 例患者（中位年龄 49（36，60）岁；20.5%为男性）无甲状旁腺功能亢进症（原发性或继发于慢性肾脏病）、甲状旁腺功能减退症或低骨量的诊断。血清 PTH 呈轻度季节性变化，3 月底（47.61pg/mL）最高，9 月底（43.15pg/mL）最低。所有性别和年龄亚组均显示春季最高，秋季最低。无论季节如何，男性的 PTH 水平均显著低于女性。PTH 与血清 25(OH)D 呈负相关，在 2800 例同时测量 25(OH)D 的患者中，血清 25(OH)D 的截断值为 12.82ng/mL。随着年龄的增长，PTH 水平升高，与血清 25(OH)D 无关。
我们在罗马尼亚发现了血清 PTH 的轻度季节性变化，与血清 25(OH)D 的变化呈反向正弦模式。PTH-25(OH)D 相关性的截断值表明，只有在高危人群中才需要补充维生素 D。
